LTA antibody (AT15A3) | MyBioSource MBS200189 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

LTA antibody (AT15A3)

catalog :

MBS200189

quantity :

0.05 ml

price :

240 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AT15A3

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS200189

products type :

Antibody

products full name :

LTA antibody (AT15A3)

products short name :

LTA

products name syn :

CLTalpha; Coley's toxin; DIF; Differentiation inducing factor; Hemorrhagic factor; LT; LT alpha; LTA; LTalpha; Lymphotoxin alpha; Lymphotoxin alpha (TNF superfamily; member 1); Natural killer cytotoxic factor; Necrosin; NKCF; OTTHuMP00000037612; OTTHuMP00000037613; TNF B; TNF superfamily member 1; TNFB; TNFbeta; TNFSF 1; TNFSF1; Tumor necrosis factor beta; Tumor necrosis factor ligand superfamily member 1; Tumor necrosis factor superfamily member 1; Lymphotoxin alpha

other names :

lymphotoxin-alpha; Lymphotoxin-alpha; lymphotoxin-alpha; LT-alpha; TNF superfamily, member 1; TNF-beta; tumor necrosis factor beta; tumor necrosis factor ligand superfamily member 1; lymphotoxin alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1

products gene name :

LTA

other gene names :

LTA; LTA; LT; TNFB; TNFSF1; TNFB; TNFSF1; LT-alpha

uniprot entry name :

TNFB_HUMAN

clonality :

Monoclonal

isotype :

IgG2b, k

clone :

AT15A3

host :

Mouse

reactivity :

Human, Mouse

sequence length :

205

purity :

By protein-G affinity chromatography

form :

Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide

concentration :

1mg/ml

storage stability :

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

tested application :

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

app notes :

The antibody has been tested by ELISA, Western blot and Immunofluorescence analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis and Immunofluorescence is 1:250 ~ 500. Recommended starting dilution is 1:250

other info1 :

Antigen Species: Human. Clone: Anti-human LTA mAb, clone AT15A3, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human LTA protein. Immunogen: Recombinant human LTA (35-205aa) purified from E.coli

products categories :

Cancer

products description :

Lymphotoxin-alpha (LT-alpha; LTA) is member of the TNF ligand superfamily, bind the same TNF receptor and mediate similar pleiotropic effect. LTA, located within the MHC III region of chromosome 6, show close linkage to the HLA class I (HLA-B) and class II (HLA-DR) genes. LTA is proinflammatory cytokine with important biological activity and immunomodulatory function and be known to influence a variety of cellular response. In particular, Polymorphism in the gene encoding LTA appears to contribute to infectious disease susceptibility and infection.

products references :

Ovsyannikova IG, et al. (2010) PLoS One, 5(7):e11806 Boraska V, et al. (2010) BMC Med Genet, 11-69. Sala A, et al. (2010) Pharmacol Rep, 62(3):503-10.

ncbi gi num :

229092381

ncbi acc num :

NP_001153212

ncbi gb acc num :

NM_001159740.2

ncbi mol weight :

22,297 Da

ncbi pathways :

Apoptosis Pathway 198797!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!HTLV-I Infection Pathway 373901!!HTLV-I Infection Pathway 373889!!Herpes Simplex Infection Pathway 377873!!Herpes Simplex Infection Pathway 377865!!IL2 Signaling Events Mediated By STAT5 Pathway 137988!!IL4-mediated Signaling Events Pathway 137933!!NF-kappa B Signaling Pathway 634527

ncbi summary :

The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

size :

0.05 ml

price :

240 USD

more info or order :

MyBioSource product webpage