Biotin-Linked Antibody to Erythropoietin Receptor (EPOR) | MyBioSource MBS2001845 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Biotin-Linked Antibody to Erythropoietin Receptor (EPOR)

catalog :

MBS2001845

quantity :

0.1 mg

price :

225 USD

clonality :

polyclonal

host :

rabbit

conjugate :

biotin

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2001845

products type :

Antibody

products full name :

Biotin-Linked Antibody to Erythropoietin Receptor (EPOR)

products short name :

[Erythropoietin Receptor (EPOR)]

other names :

[erythropoietin receptor; Erythropoietin receptor; erythropoietin receptor; erythropoietin receptor]

products gene name :

[EPOR]

other gene names :

[EPOR; EPOR; EPO-R; EPO-R]

uniprot entry name :

EPOR_HUMAN

clonality :

Polyclonal

host :

Rabbit

purity :

Antigen-specific Affinity Chromatography.

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

concentration :

0.33mg/ml

storage stability :

Storage: Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

WB; IHC; ICC.

app notes :

Western blotting: 0.5-2ug/mL;1:160-660. Immunohistochemistry: 5-20ug/mL;1:16-66. Immunocytochemistry: 5-20ug/mL;1:16-66. Optimal working dilutions must be determined by end user.

other info1 :

Organism Species: Homo sapiens (Human). Source: Antibody labeling. Label: Biotin. Traits: Liquid. Immunogen: Recombinant EPOR (Arg276~Ala496) expressed in E.coli.

other info2 :

Unconjugated Antibody: The unconjugated antibody version of this item is also available as catalog #MBS2003188

products categories :

Biotin Antibody

ncbi gi num :

4503591

ncbi acc num :

NP_000112.1

ncbi gb acc num :

NM_000121.3

uniprot acc num :

P19235

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); EPO Receptor Signaling Pathway (198882); EPO Signaling Pathway (138051); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); Kit Receptor Signaling Pathway (198826); PI3K-Akt Signaling Pathway (692234)

ncbi summary :

This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

uniprot summary :

EPOR: erythropoietin receptor: a member of the cytokine receptor family. Mediates erythropoietin-induced erythroblast proliferation, differentiation and survival. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. Forms homodimers on EPO stimulation. Tyrosine-phosphorylated EpoR may bind several SH2 domain-containing proteins including LYN, the adapter protein APS, SHP-1, SHP-2, JAK2, PI3 kinases, STAT5A/B, SOCS3, and CRKL. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Three alternatively-spliced isoforms have been described. Isoform EPOR-T, missing the cytoplasmic tail, acts as a dominant-negative receptor of EPOR-mediated signaling. Protein type: Receptor, cytokine; Membrane protein, integral. Chromosomal Location of Human Ortholog: 19p13.3-p13.2. Cellular Component: integral to plasma membrane; extracellular region. Molecular Function: identical protein binding; protein binding; erythropoietin receptor activity. Biological Process: heart development; brain development; decidualization; signal transduction. Disease: Erythrocytosis, Familial, 1

size1 :

0.1 mg

price1 :

225 USD

size2 :

0.2 mg

price2 :

335

size3 :

1 mg

price3 :

795

more info or order :

MyBioSource product webpage