OAT antibody (AT23A2) | MyBioSource MBS200183 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

OAT antibody (AT23A2)

catalog :

MBS200183

quantity :

0.05 mL

price :

240 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AT23A2

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS200183

products type :

Antibody

products full name :

OAT antibody (AT23A2)

products short name :

OAT

products name syn :

DKFZp781A11155; HOGA; OATASE; ornithine aminotransferase precursor EC 2.6.1.13; ornithine aminotransferase (gyrate atrophy); ornithine aminotransferase precursor; Ornithine aminotransferase; mitochondrial precursor; Ornithine oxo-acid aminotransferase; Ornithine--oxo-acid aminotransferase.

other names :

ornithine aminotransferase, mitochondrial isoform 1; Ornithine aminotransferase, mitochondrial; ornithine aminotransferase, mitochondrial; gyrate atrophy; ornithine delta-aminotransferase; ornithine-oxo-acid aminotransferase; ornithine aminotransferase; Ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferaseCleaved into the following 2 chains:Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form

products gene name :

OAT

other gene names :

OAT; OAT; OKT; GACR; HOGA; OATASE

uniprot entry name :

OAT_HUMAN

clonality :

Monoclonal

isotype :

IgG1, k

clone :

AT23A2

host :

Mouse

reactivity :

Human, Mouse

sequence length :

439

purity :

By protein-G affinity chromatography

form :

Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide

concentration :

1mg/ml

storage stability :

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

tested application :

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

app notes :

The antibody has been tested by ELISA, Western blot and Immunofluorescence analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis and Immunofluorescence is 1:250 ~ 500. Recommended starting dilution is 1:250

other info1 :

Antigen Species: Human. Clone: Anti-human OAT mAb, clone AT23A2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human OAT protein. Immunogen: Recombinant human OAT (33-439aa) purified from E.coli

products categories :

Neuroscience

products description :

OAT is a 49-kDa nucleus-encoded protein imported into mitochondria to give the mature 48-kDa OAT polypeptide. It has been described in humans, animals, insects, plants and microorganisms. Especially OAT have sex-differential expression in the mouse kidney. OAT plays crucial physiological roles in amino acid metabolism. OAT shows a large structural and mechanistic similarity to other enzymes from the subgroup III of aminotransferases, which transfer an amino group from a carbon atom that does not carry a carboxyl function. OAT is essential for nitrogen recycling from arginine but not for the stress-induced proline accumulation.

products references :

Stranska J, et al. (2008) Plant Signal Behav, 3(11):929-35. Canas RA, et al. (2008) Plant Physiol, 148(1):77-88. Levillain O, et al. (2007) Am J Physiol Renal Physiol, 292(3):F1016-27.

ncbi gi num :

4557809

ncbi acc num :

NP_000265

ncbi gb acc num :

NM_000274.3

ncbi mol weight :

32,853 Da

ncbi pathways :

Amino Acid Synthesis And Interconversion (transamination) Pathway (106173); Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169); Urea Cycle And Metabolism Of Amino Groups Pathway (198758); Arginine Degradation I (arginase Pathway) (138167); Citrulline Biosynthesis Pathway (138212); Ornithine De Novo Biosynthesis Pathway (142133)

ncbi summary :

This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010]

uniprot summary :

OAT: Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA). HOGA is a slowly progressive blinding autosomal recessive disorder. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Mitochondrial; Amino Acid Metabolism - arginine and proline; EC 2.6.1.13; Transferase. Chromosomal Location of Human Ortholog: 10q26. Cellular Component: mitochondrion; mitochondrial matrix. Molecular Function: ornithine-oxo-acid transaminase activity; pyridoxal phosphate binding. Biological Process: visual perception; amino acid biosynthetic process. Disease: Gyrate Atrophy Of Choroid And Retina

size1 :

0.05 mL

price1 :

240 USD

size2 :

0.1 mL

price2 :

315

more info or order :

MyBioSource product webpage