AURKB antibody (AT2B1) | MyBioSource MBS200181 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

AURKB antibody (AT2B1)

catalog :

MBS200181

quantity :

0.05 ml

price :

240 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AT2B1

reactivity :

human

application :

ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS200181

products type :

Antibody

products full name :

AURKB antibody (AT2B1)

products short name :

AURKB

products name syn :

Serine/threonine-protein kinase 12; Aurora-B; AIK2; AIM1; ARK2; AurB; aurkb-sv1; aurkb-sv2; IPL1; STK12; aurkb; AIM1; AuRKB; Aurora 1; STK1; STK5; Aurora and Ipl1 like midbody associated protein 1; Aurora kinase B; Aurora related kinase 2; Aurora/IPL1 related kinase 2; Serine/theronine kinase 12; Serine/threonine protein kinase 12

other names :

aurora kinase B isoform 1; Aurora kinase B; aurora kinase B; ARK-2; STK-1; aurora 1; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora- and Ipl1-like midbody-associated protein 1; aurora-1; aurora-B; aurora-related kinase 2; aurora/IPL1-related kinase 2; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; serine/threonine-protein kinase 12; serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B; aurora kinase B; Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B

products gene name :

AURKB

other gene names :

AURKB; AURKB; AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2; AIK2; AIM1; AIRK2; ARK2; STK1; STK12; STK5; AIM-1; ARK-2; Aurora-related kinase 2

uniprot entry name :

AURKB_HUMAN

clonality :

Monoclonal

isotype :

IgG2b, k

clone :

AT2B1

host :

Mouse

reactivity :

Human

sequence length :

344

purity :

By protein-G affinity chromatography

form :

Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide

concentration :

1mg/ml

storage stability :

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

tested application :

ELISA (EIA), Immunofluorescence (IF)

app notes :

The antibody has been tested by ELISA and Immunofluorescence analyses to assure specificity and reactivity. Since applications vary, each investigation should be titrated by a reagent to obtain optimal results. Recommended dilution range for Immunofluorescence is 1:1000 ~ 2000. Recommended starting dilution is 1:1000

other info1 :

Antigen Species: Human. Clone: Anti-human Aurora kinase B mAb, clone AT2B1, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Aurora kinase B protein. Immunogen: Recombinant human Aurora kinase B (1-344aa) purified from E Coli

products categories :

Cell Cycle

products description :

The aurora family (A, B and C) are serine threonine kinases and key regulators of chromosome segregation during mitosis. Aurora kinase B is a chromosomal passenger protein that regulates chromosome segregation and cytokinesis. Aurora kinase B is associated with the level of genetic instability within tumours and patient survival. It is strongly expressed in exponentially proliferating bronchial epithelial cells in culture and that this expression is markedly reduced in confluent cells. It is also shown that almost all tumours show higher levels of Aurora kinase B expression than their matched normal lung tissues, which could therefore simply be a consequence of a higher proliferative index, or be typical of the progenitor cell and atypical of the bulk of normal lung cells

products references :

Posch M, et al. (2010) J Cell Biol, 191(1):61-74. Lisa L, et al. (2009) J Cell Biol, 186(4): 491-507. S L Smith, et al. (2005) Br J Cancer, 93(6): 719-729.

ncbi gi num :

83776600

ncbi acc num :

NP_004208

ncbi gb acc num :

NM_004217.3

ncbi mol weight :

39,467 Da

ncbi pathways :

APC/C-mediated Degradation Of Cell Cycle Proteins Pathway 105825!!APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway 105835!!Aurora A Signaling Pathway 137925!!Aurora B Signaling Pathway 138080!!Aurora C Signaling Pathway 138003!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!FOXM1 Transcription Factor Network Pathway 137935!!M Phase Pathway 105812!!Mitotic Anaphase Pathway 105818

ncbi summary :

This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

size :

0.05 ml

price :

240 USD

more info or order :

MyBioSource product webpage