catalog number :
MBS2001804
products full name :
Polyclonal Antibody to Annexin A1 (ANXA1)
products short name :
[Annexin A1 (ANXA1)]
other names :
[annexin A1; Annexin A1; annexin A1; Annexin I]
products gene name :
[ANXA1]
other gene names :
[ANXA1; ANXA1; ANX1; ANX1]
purity :
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
form :
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
Western Blotting, Immunohistochemistry (IHC), Immunocytochemistry (ICC),Immunoprecipitation (IP).
app notes :
Western blotting: 0.5-2 ug/mL;1:500-2000. Immunohistochemistry: 5-20 ug/mL;1:50-200. Immunocytochemistry: 5-20 ug/mL;1:50-200.
Optimal working dilutions must be determined by end user.
image1 heading :
Western Blot (WB)
image2 heading :
Western Blot (WB)
other info1 :
Organism Species: Sus scrofa; Porcine (Pig). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant ANXA1 (Glu208~Glu336 (Accession # P19619)) expressed in E.coli
other info2 :
Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2075499
ncbi acc num :
NP_001157470.1
ncbi gb acc num :
NM_001163998.1
uniprot summary :
Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (). Has no effect on unstimulated T-cells. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (). Has high affinity for Ca2+ and can bind up to eight Ca2+ ions (PubMed:12595246). Displays Ca2+-dependent binding to phospholipid membranes (PubMed:8885232). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca2+-dependent interaction between phagosomes and the actin cytoskeleton ().