catalog number :
MBS2001703
products full name :
Polyclonal Antibody to Matrix Gla Protein (MGP)
products short name :
[Matrix Gla Protein (MGP)]
other names :
[matrix Gla protein; Matrix Gla protein; matrix Gla protein; matrix Gla protein]
products gene name :
[MGP]
other gene names :
[Mgp; Mgp; Mglap; MGP]
specificity :
The antibody is a rabbit polyclonal antibody raised against MGP. It has been selected for its ability to recognize MGP in immunohistochemical staining andwestern blotting.
purity :
Affinity Chromatography
form :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
storage stability :
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
tested application :
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
app notes :
Western blotting: 1:50-400. Immunocytochemistry in formalin fixed cells: 1:50-500. Immunohistochemistry in formalin fixed frozen section: 1:50-500. Immunohistochemistry in paraffin section: 1:10-100. Enzyme-linked Immunosorbent Assay: 1:100-5000. Optimal working dilutions must be determined by end user.
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: MGP, Rat. Immunogen Information: Recombinant MGP (Tyr20~Lys103) with two N-terminal Tags,
His-tag and S-tag expressed in E.coli. Accession No.: RPB477Ra01
other info2 :
Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2055632
ncbi acc num :
NP_036994.1
ncbi gb acc num :
NM_012862.1
ncbi mol weight :
12,037 Da
ncbi pathways :
Endochondral Ossification Pathway (219771)
ncbi summary :
a vitamin K-dependent protein; part of the bone matrix [RGD, Feb 2006]
uniprot summary :
MGP: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. Defects in MGP are the cause of Keutel syndrome (KS). KS is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia. Belongs to the osteocalcin/matrix Gla protein family. Protein type: Extracellular matrix; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 4q43. Cellular Component: endoplasmic reticulum; extracellular exosome; extracellular matrix; extracellular space; protein complex. Molecular Function: calcium ion binding; calcium-dependent protein binding; extracellular matrix structural constituent. Biological Process: branching morphogenesis of a tube; cartilage development; cell differentiation; lung development; ossification; protein complex assembly; regulation of bone mineralization; response to calcium ion; response to glucocorticoid stimulus; response to hormone; response to mechanical stimulus; response to nutrient; response to organic substance