product summary
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company name :
MyBioSource
product type :
antibody
product name :
Casein Kinase 1 alpha antibody (clone AT2E2)
catalog :
MBS200165
quantity :
0.05 ml
price :
240 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
AT2E2
reactivity :
human
application :
western blot, ELISA, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS200165
products type :
Antibody
products full name :
Casein Kinase 1 alpha antibody (clone AT2E2)
products short name :
Casein Kinase 1 alpha
products name syn :
Casein Kinase 1 alpha; CK1
other names :
casein kinase I isoform alpha isoform 2; Casein kinase I isoform alpha; casein kinase I isoform alpha; CKI-alpha; clock regulator kinase; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p; casein kinase 1, alpha 1; CK1
other gene names :
CSNK1A1; CSNK1A1; CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p; CKI-alpha
uniprot entry name :
KC1A_HUMAN
clonality :
Monoclonal
isotype :
IgG2b, k
clone :
AT2E2
host :
Mouse
reactivity :
Human
sequence length :
337
purity :
By protein-G affinity chromatography
form :
Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.
concentration :
1mg/ml
storage stability :
Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1000 ~ 2000. Recommended starting dilution is 1:1000.
other info1 :
Antigen Species: Human. Clone: Anti-human Casein Kinase 1 alpha mAb, clone AT2E2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Casein Kinase 1 alpha protein. Immunogen: Recombinant human Casein Kinase 1 alpha (1-337aa) purified from E Coli
products categories :
Signal Transduction
products description :
Caseine Kinase 1 alpha belongs to the protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily. CK1 isoforms (alpha, beta, gamma, delta, epsilon) and their splice variants are involved in diverse cellular processes including membrane trafficking, circadian rhythm, cell cycle progression, chromosome segregation, apoptosis and cellular differentiation. Perhaps it can phosphorylate a large number of proteins and is involved in Wnt signaling where it phosphorylates CTNNB1 on Ser45. Caseine kinase 1 alpha also interacts with the Axin complex
products references :
Knippschild U, et al., (2005) Onkologie. 28(10):508-14 Katoh M., (2007) Clin Cancer Res. 13(14):4042-5
ncbi gi num :
68303572
ncbi acc num :
NP_001883
ncbi gb acc num :
NM_001892.5
ncbi mol weight :
37,567 Da
ncbi pathways :
AMER1 Mutants Destabilize The Destruction Complex Pathway 1127621!!APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway 1127616!!APC Truncation Mutants Have Impaired AXIN Binding Pathway 1127617!!AXIN Missense Mutants Destabilize The Destruction Complex Pathway 1127620!!AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway 1127618!!Activation Of SMO Pathway 1127544!!Beta-catenin Phosphorylation Cascade Pathway 106512!!Canonical Wnt Signaling Pathway 138032!!Degradation Of GLI2 By The Proteasome Pathway 1127540!!Degradation Of Beta-catenin By The Destruction Complex Pathway 106511
size :
0.05 ml
price :
240 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

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