Polyclonal Antibody to Solute Carrier Family 30 Member 8 (SLC30A8) | MyBioSource MBS2001622 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Polyclonal Antibody to Solute Carrier Family 30 Member 8 (SLC30A8)

catalog :

MBS2001622

quantity :

0.01 mg

price :

135 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2001622

products type :

Antibody

products full name :

Polyclonal Antibody to Solute Carrier Family 30 Member 8 (SLC30A8)

products short name :

Solute Carrier Family 30 Member 8 (SLC30A8)

other names :

solute carrier family 30 member 8; Zinc transporter 8; zinc transporter 8; zinc transporter ZnT-8; solute carrier family 30 (zinc transporter), member 8; Solute carrier family 30 member 8

products gene name :

SLC30A8

other gene names :

SLC30A8; SLC30A8; ZNT8; ZnT-8; ZNT8; ZnT-8

uniprot entry name :

ZNT8_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

369

sequence :

The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSGSEF-TITILKDF SILLMEGVPK SLNYSGVKEL ILAVDGVLSV HSLHIWSLTM NQVILSAHVA TAASRDSQVV RREIAKALSK SFTMHSLTIQ MESPVDQDPD CLFCEDPCD

specificity :

The antibody is a rabbit polyclonal antibody raised against SLC30A8. It has been selected for its ability to recognize SLC30A8 in immunohistochemical staining andwestern blotting.

purity :

Affinity Chromatography

form :

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.

concentration :

200ug/ml

storage stability :

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

tested application :

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

app notes :

Western blotting: 1:50-400. Immunocytochemistry in formalin fixed cells: 1:50-500. Immunohistochemistry in formalin fixed frozen section: 1:50-500. Immunohistochemistry in paraffin section: 1:10-100. Enzyme-linked Immunosorbent Assay: 1:100-5000. Optimal working dilutions must be determined by end user.

other info1 :

Immunogen: Recombinant SLC30A8 (Thr263~Asp369) expressed in E.coli. Immunogen: SLC30A8, Human. Immunogen: Recombinant SLC30A8 (Thr263~Asp369) with N-terminal His-Tag expressed in E.coli. Accession No.: RPE490Hu01

ncbi gi num :

27447432

ncbi acc num :

AAM80562.1

uniprot acc num :

Q8IWU4

ncbi mol weight :

40,755 Da

ncbi pathways :

Metal Ion SLC Transporters Pathway (161066); SLC-mediated Transmembrane Transport Pathway (119558); Transmembrane Transport Of Small Molecules Pathway (106572); Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway (119571); Zinc Efflux And Compartmentalization By The SLC30 Family Pathway (161068); Zinc Transporters Pathway (161067)

ncbi summary :

The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

uniprot summary :

SLC30A8: Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transporter, SLC family; Vesicle; Transporter; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 8q24.11. Cellular Component: Golgi apparatus; secretory granule membrane; cytoplasmic membrane-bound vesicle; plasma membrane; integral to membrane; secretory granule. Molecular Function: protein homodimerization activity; zinc ion binding; zinc ion transmembrane transporter activity. Biological Process: sequestering of zinc ion; cellular protein metabolic process; insulin secretion; cellular zinc ion homeostasis; response to glucose stimulus; positive regulation of insulin secretion; zinc ion transport; glucose homeostasis; transmembrane transport. Disease: Diabetes Mellitus, Noninsulin-dependent

size1 :

0.01 mg

price1 :

135 USD

size2 :

0.05 mg

price2 :

235

size3 :

0.1 mg

price3 :

320

more info or order :

MyBioSource product webpage