Biotin-Linked Antibody to A Disintegrin And Metalloprotease 9 (ADAM9) | MyBioSource MBS2001583 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Biotin-Linked Antibody to A Disintegrin And Metalloprotease 9 (ADAM9)

catalog :

MBS2001583

quantity :

0.1 mg

price :

415 USD

clonality :

polyclonal

host :

rabbit

conjugate :

biotin

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2001583

products type :

Antibody

products full name :

Biotin-Linked Antibody to A Disintegrin And Metalloprotease 9 (ADAM9)

products short name :

A Disintegrin And Metalloprotease 9 (ADAM9)

other names :

A disintegrin and metalloproteinase with thrombospondin motifs 9 preproprotein; A disintegrin and metalloproteinase with thrombospondin motifs 9; A disintegrin and metalloproteinase with thrombospondin motifs 9; ADAM-TS9; ADAMTS-9; ADAM-TS 9; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9; ADAM metallopeptidase with thrombospondin type 1 motif, 9

products gene name :

ADAM9

other gene names :

ADAMTS9; ADAMTS9; KIAA1312; ADAM-TS 9; ADAM-TS9; ADAMTS-9

uniprot entry name :

ATS9_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

1935

specificity :

The antibody is a rabbit polyclonal antibody raised against ADAM9 conjugated to biotin. It has been selected for its ability to recognize ADAM9 in immunohistochemical staining andwestern blotting.

purity :

Affinity Chromatography

form :

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.

concentration :

200ug/ml

storage stability :

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

tested application :

Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)

app notes :

Western blotting: 1:100-400. Immunocytochemistry in formalin fixed cells: 1:100-500. Immunohistochemistry in formalin fixed frozen section: 1:100-500. Immunohistochemistry in paraffin section: 1:50-200. Enzyme-linked Immunosorbent Assay: 1:100-200

other info2 :

Conjugation: Biotin

products categories :

Biotin Antibody

ncbi gi num :

33624896

ncbi acc num :

NP_891550.1

ncbi gb acc num :

NM_182920.1

uniprot acc num :

Q9P2N4

ncbi mol weight :

216,491 Da

ncbi pathways :

Degradation Of The Extracellular Matrix Pathway 576263!!Degradation Of The Extracellular Matrix Pathway 934113!!Extracellular Matrix Organization Pathway 576262!!Extracellular Matrix Organization Pathway 934100

uniprot summary :

Function: Cleaves the large aggregating proteoglycans, aggrecan and versican. Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. Ref.2 Ref.6. Catalytic activity: Cleaves aggrecan at the 1838-Glu- -Ala-1839 site and versican at the 1428-Glu- -Ala-1429 site. Cofactor: Binds 1 zinc ion per subunit . By similarity. Subcellular location: Secreted extracellular space extracellular matrix . By similarity. Endoplasmic reticulum Ref.6. Tissue specificity: Highly expressed in all fetal tissues. Expressed in a number of adult tissues with highest expression in heart, placenta and skeletal muscle. Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix . By similarity.The ancillary domains, including the TSRs domain, are required for specific extracellular localization and for its versicanase and aggrecanase activities.The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.The GON domain mediates protease-independent function in ER to Golgi transport. Post-translational modification: The precursor is cleaved by a furin endopeptidase . By similarity.Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion . By similarity. Sequence similarities: Contains 1 disintegrin domain.Contains 1 GON domain.Contains 1 peptidase M12B domain.Contains 15 TSP type-1 domains.

size :

0.1 mg

price :

415 USD

more info or order :

MyBioSource product webpage