catalog number :
MBS2001525
products full name :
Polyclonal Antibody to Regenerating Islet Derived Protein 1 Alpha (REG1a)
products short name :
[Regenerating Islet Derived Protein 1 Alpha (REG1a)]
other names :
[lithostathine-1-alpha; Lithostathine-1-alpha; lithostathine-1-alpha; regenerating family member 1 alpha; Islet cells regeneration factor; ICRF; Islet of Langerhans regenerating protein; REG; Pancreatic stone protein; PSP; Pancreatic thread protein; PTP; Regenerating islet-derived protein 1-alpha; REG-1-alpha; Regenerating protein I alpha]
products gene name :
[REG1a]
other gene names :
[REG1A; REG1A; P19; PSP; PTP; REG; ICRF; PSPS; PSPS1; PSPS; PSPS1; REG; ICRF; REG; PSP; PTP; REG-1-alpha]
purity :
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
form :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
storage stability :
Storage:. Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 24 months. Stability Test:. The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blot (WB), Immunoprecipitation (IP)
app notes :
Western blotting: 0.5-2ug/mL. Immunohistochemistry: 5-20ug/mL. Immunocytochemistry: 5-20ug/mL. Optimal working dilutions must be determined by end user.
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Organism Species: Homo sapiens (Human). Source: Polyclonal antibody preparation
other info2 :
Traits: Liquid. Immunogen: Recombinant REG1a (Arg33~Asn166 (Accession # P05451)) expressed in E.coli
ncbi acc num :
NP_002900.2
ncbi gb acc num :
NM_002909.4
ncbi pathways :
Insulin Signaling Pathway (198845); Type II Interferon Signaling (IFNG) Pathway (198918)
ncbi summary :
This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]
uniprot summary :
REG1A: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 2p12. Molecular Function: carbohydrate binding; growth factor activity. Biological Process: positive regulation of cell proliferation