catalog number :
MBS2001518
products full name :
Polyclonal Antibody to Peroxidasin Homolog (PXDN)
products short name :
[Peroxidasin Homolog (PXDN)]
other names :
[peroxidasin homolog; Peroxidasin homolog; peroxidasin homolog; peroxidasin; Melanoma-associated antigen MG50; Vascular peroxidase 1; p53-responsive gene 2 protein]
products gene name :
[PXDN]
other gene names :
[PXDN; PXDN; PXN; VPO; MG50; PRG2; ASGD7; COPOA; D2S448; D2S448E; KIAA0230; MG50; PRG2; VPO; VPO1]
purity :
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
form :
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
concentration :
0.28 mg/ml
storage stability :
Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
tested application :
WB; IHC; ICC; IP.
app notes :
Western blotting: 0.5-2 ug/mL;1:140-550. Immunohistochemistry: 5-20 ug/mL;1:14-55. Immunocytochemistry: 5-20(g/mL;1:14-55. Optimal working dilutions must be determined by end user.
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Organism Species: Homo sapiens (Human). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant PXDN (Gln1285~Ala1475 (Accession # Q92626)) expressed in E.coli
other info2 :
Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2083595
ncbi acc num :
NP_036425.1
ncbi gb acc num :
NM_012293.2
ncbi summary :
This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations in this gene cause corneal opacification and other ocular anomalies, and also microphthalmia and anterior segment dysgenesis. [provided by RefSeq, Aug 2014]
uniprot summary :
PXDN: Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular matrix formation. Belongs to the peroxidase family. XPO subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 1.11.1.7; Oxidoreductase; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 2p25.3. Cellular Component: endoplasmic reticulum; extracellular matrix; extracellular region; extracellular space; proteinaceous extracellular matrix. Molecular Function: extracellular matrix structural constituent; heme binding; interleukin-1 receptor antagonist activity; metal ion binding; peroxidase activity. Biological Process: extracellular matrix organization; hydrogen peroxide catabolic process; immune response; negative regulation of cytokine and chemokine mediated signaling pathway; response to oxidative stress. Disease: Corneal Opacification With Other Ocular Anomalies