FkBP4 antibody (clone AT4D3) | MyBioSource MBS200141 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FkBP4 antibody (clone AT4D3)

catalog :

MBS200141

quantity :

0.05 ml

price :

240 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AT4D3

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS200141

products type :

Antibody

products full name :

FkBP4 antibody (clone AT4D3)

products short name :

FkBP4

products name syn :

FKBP52; FKBP59; HBI; Hsp56; p52; PPIase; FK506 binding protein 4 52 kDa FK506 binding protein; FKBP 4; FKBP 52; FKBP 59; FKBP4; FKBP52 protein; FKBP59; Hsp 56; HSP binding immunophilin; p59 protein; PPIase; Rotamase; Peptidyl prolyl cis trans isomerase; Peptidylprolyl cis trans isomerase; T cell FK506 binding protein 59kD.

other names :

peptidyl-prolyl cis-trans isomerase FKBP4; Peptidyl-prolyl cis-trans isomerase FKBP4; peptidyl-prolyl cis-trans isomerase FKBP4; 51 kDa FK506-binding protein; FK506-binding protein 4 (59kD); HSP binding immunophilin; T-cell FK506-binding protein, 59kD; peptidylprolyl cis-trans isomerase; rotamase; FK506 binding protein 4, 59kDa; 51 kDa FK506-binding protein; FKBP51; 52 kDa FK506-binding protein; 52 kDa FKBP; FKBP-52; 59 kDa immunophilin; p59; FK506-binding protein 4; FKBP-4; FKBP59; HSP-binding immunophilin; HBI; Immunophilin FKBP52; RotamasePeptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed

products gene name :

FkBP4

other gene names :

FKBP4; FKBP4; HBI; p52; Hsp56; FKBP51; FKBP52; FKBP59; PPIase; FKBP52; PPIase FKBP4; FKBP51; 52 kDa FKBP; FKBP-52; p59; FKBP-4; HBI

uniprot entry name :

FKBP4_HUMAN

clonality :

Monoclonal

isotype :

IgG2b, k

clone :

AT4D3

host :

Mouse

reactivity :

Human

sequence length :

459

purity :

By protein-G affinity chromatography

form :

Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

concentration :

1mg/ml

storage stability :

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

tested application :

ELISA (EIA), Western Blot (WB) (Cell lysate), Immunohistochemistry (IHC)

app notes :

The antibody has been tested by ELISA, Western blot and immunohistochemistry analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot is 1:1,000 ~ 1:2,000 and immunohistochemistry analysis is 1:50~100. Recommended starting dilution for Western blot is 1:1,000 and Immunohistochemistry is 1:50.

other info1 :

Antigen Species: Human. Clone: Anti-human FkBP4 mAb, clone AT4D3, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human FkBP4 protein. Immunogen: Recombinant human FkBP4 (1-459aa) purified from E Coli

products categories :

Redox Proteins

products description :

FkBP4, also known as FkBP52, is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. It is a component of unactivated mammalian steroid receptor complexes and may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes.

products references :

Ostrow kL, et al., (2009) Clin Cancer Res. 15(4):1184-91 Ma D, et al., (2008) J Biol Chem. 283(38):25963-70

ncbi gi num :

4503729

ncbi acc num :

NP_002005

ncbi gb acc num :

NM_002014.3

ncbi mol weight :

51,805 Da

ncbi pathways :

Androgen Receptor Signaling Pathway 198806!!Attenuation Phase Pathway 1127556!!Cellular Response To Heat Stress Pathway 1127553!!Cellular Responses To Stress Pathway 645258!!Coregulation Of Androgen Receptor Activity Pathway 138085!!Estrogen Signaling Pathway 799177!!Estrogen Signaling Pathway 799197!!Glucocorticoid Receptor Regulatory Network Pathway 138014!!HSF1-dependent Transactivation Pathway 1127555

ncbi summary :

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]

size :

0.05 ml

price :

240 USD

more info or order :

MyBioSource product webpage