Monoclonal anti-human CHI3L1 antibody (clone AT4A3) | MyBioSource MBS200140 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Monoclonal anti-human CHI3L1 antibody (clone AT4A3)

catalog :

MBS200140

quantity :

0.05 mL

price :

240 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AT4A3

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS200140

products type :

Antibody

products full name :

Monoclonal anti-human CHI3L1 antibody (clone AT4A3)

products short name :

CHI3L1

products name syn :

chitinase 3-like 1 precursor; chitinase 3-like 1 (cartilage glycoprotein-39); GP39; YKL40

other names :

chitinase-3-like protein 1; Chitinase-3-like protein 1; chitinase-3-like protein 1; 39 kDa synovial protein; cartilage glycoprotein 39; chitinase 3-like 1 (cartilage glycoprotein-39); 39 kDa synovial protein; Cartilage glycoprotein 39; CGP-39; GP-39; hCGP-39; YKL-40

products gene name :

CHI3L1

other gene names :

CHI3L1; CHI3L1; GP39; ASRT7; GP-39; YKL40; CGP-39; YKL-40; YYL-40; HC-gp39; HCGP-3P; hCGP-39; CGP-39; GP-39; hCGP-39

uniprot entry name :

CH3L1_HUMAN

clonality :

Monoclonal

isotype :

Mouse IgG2b heavy chain and kappa light chain

clone :

AT4A3

host :

Mouse

reactivity :

Human

sequence length :

383

purity :

By protein-G affinity chromatography

form :

Liquid. in Phosphate-Buffer Saline (pH7.4) with 0.02% Sodium Azide, 10% Glycerol.

concentration :

1mg/ml

storage stability :

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

tested application :

ELISA (EIA), Western Blot (WB) (Cell lysate)

app notes :

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:250 ~ 1500. Recommended starting dilution is 1:250

other info1 :

Antigen Species: Human. Clone: Anti-human CHI3L1 mAb, clone AT4A3, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CHI3L1 protein. Immunogen: Recombinant human CHI3L1 (22-383aa) purified from E Coli

products categories :

Cytoskeleton

products description :

Chitinase 3-Like-1 (CHI3L1) is a recently discovered human glycoprotein which is related in amino acid sequence to the chitinase protein family, but has no chitinase activity. CHI3L1 is upregulated in a number of cancers and in non-neoplatic disease states characterized by chronic inflammation and tissue remodeling. Its pattern of expression is associated with pathogenic processes related to inflammation, extracellular tissue remodeling, fibrosis and solid carcinomas. CHI3L1 may play an important role in the capacity of cells to respond to and cope with changes in their environment.

products references :

kazakova MH, et al., (2009) Folia Med. 51(1):5-14 Bonneh-Barkay D, et al., (2008) Am J Pathol. 173(1):130-43

ncbi gi num :

144226251

ncbi acc num :

NP_001267

ncbi gb acc num :

NM_001276.2

ncbi mol weight :

42,625 Da

ncbi summary :

Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]

uniprot summary :

CHI3L1: Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment. A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7). Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis. Belongs to the glycosyl hydrolase 18 family. Protein type: Cell adhesion; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1q32.1. Cellular Component: proteinaceous extracellular matrix; extracellular space; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm. Molecular Function: extracellular matrix structural constituent; chitin binding; chitinase activity; carbohydrate binding. Biological Process: positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; apoptosis; response to mechanical stimulus; cartilage development; carbohydrate metabolic process; activation of NF-kappaB-inducing kinase; immune response; chitin catabolic process; inflammatory response; lung development. Disease: Schizophrenia; Asthma-related Traits, Susceptibility To, 7

size1 :

0.05 mL

price1 :

240 USD

size2 :

0.1 mL

price2 :

315

more info or order :

MyBioSource product webpage