catalog number :
MBS200137
products full name :
MAT2A antibody (clone AT3A2)
products short name :
MAT2A
products name syn :
MATA2; MATII; SAMS2; Methionine adenosyltransferase II alpha; MAT2A; Methionine adenosyltransferase II; alpha AdoMet synthetase; AdoMet synthetase 2; AMS 2; MAT II; MATA 2; Methionine adenosyltransferase; Methionine adenosyltransferase 2; SAMS 2; Methionine adenosyltransferase II; S adenosylmethionine synthetase gamma form; S adenosylmethionine synthetase isoform type 2; S-adenosylmethionine synthetase isoform type 2
other names :
S-adenosylmethionine synthase isoform type-2; S-adenosylmethionine synthase isoform type-2; S-adenosylmethionine synthase isoform type-2; MAT 2; MAT-II; adoMet synthase 2; adoMet synthetase 2; methionine adenosyltransferase 2; methionine adenosyltransferase II, alpha; Methionine adenosyltransferase 2; MAT 2; Methionine adenosyltransferase II; MAT-II
products gene name :
MAT2A
other gene names :
MAT2A; MAT2A; MATA2; MATII; SAMS2; AMS2; MATA2; AdoMet synthase 2; MAT 2; MAT-II
uniprot entry name :
METK2_HUMAN
purity :
By protein-G affinity chromatography
form :
Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.
storage stability :
Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.
tested application :
ELISA (EIA), Western Blot (WB) (Cell lysate), Immunohistochemistry (IHC)
app notes :
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1000 ~ 2000. Recommended starting dilution is 1:1000.
other info1 :
Antigen Species: Human. Clone: Anti-human MAT2A mAb, clone AT3A2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human MAT2A protein. Immunogen: Recombinant human MAT2A (1-395aa) purified from E Coli
products categories :
Metabolism
products description :
Methionine adenosyltransferase II (MAT II) is a key enzyme in cellular metabolism and catalyzes the formation of S-adenosylmethionine (SAMe) from L-methionine and ATP. MAT2A is expressed in extrahepatic tissues. In liver, MAT2A expression associates with growth, dedifferentiation, and cancer.
products references :
Ramani k, et al., (2008) Hepatology 47(2):521-531 Chen H, et al., (2007) Gastroenterology 133(1):207-218
ncbi gb acc num :
NM_005911.5
ncbi mol weight :
32,965 Da
ncbi pathways :
Biological Oxidations Pathway 105698!!Biosynthesis Of Amino Acids Pathway 790012!!Biosynthesis Of Amino Acids Pathway 795174!!C-MYB Transcription Factor Network Pathway 138073!!Cysteine And Methionine Metabolism Pathway 104488!!Cysteine And Methionine Metabolism Pathway 103421!!Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway 1127639!!Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway 1127658!!Defective GGT1 Causes Glutathionuria (GLUTH) Pathway 1127659!!Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway 1127660
ncbi summary :
The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]