Monoclonal Antibody to Adrenomedullin (ADM) | MyBioSource MBS2001363 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Monoclonal Antibody to Adrenomedullin (ADM)

catalog :

MBS2001363

quantity :

0.02 mg

price :

135 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2001363

products type :

Antibody

products full name :

Monoclonal Antibody to Adrenomedullin (ADM)

products short name :

Adrenomedullin (ADM)

other names :

adrenomedullin; ADM; ADM; preproadrenomedullin; adrenomedullin; ProAM N-terminal 20 peptide

products gene name :

ADM

other gene names :

ADM; ADM; AM; AM; AM; PAMP; ProAM-N20

uniprot entry name :

ADML_HUMAN

clonality :

Monoclonal

isotype :

IgG1 Kappa

clone :

host :

Mouse

reactivity :

Human

sequence length :

185

sequence :

The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSGSEF-ARLDVASEF RKKWNKWALS RGKRELRMSS SYPTGLADVK AGPAQTLIRP QDMKGASRSP EDSSPDAARI RVKRYRQSMN NFQGLRSFGC

specificity :

The antibody is a mouse monoclonal antibody raised against ADM. It has been selected for its ability to recognize ADM in immunohistochemical staining and western blotting.

purity :

Affinity Chromatography

form :

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.

concentration :

500ug/mL

storage stability :

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

tested application :

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

app notes :

Western blotting: 1:100-400. Immunocytochemistry in formalin fixed cells: 1:100-500. Immunohistochemistry in formalin fixed frozen section: 1:100-500. Immunohistochemistry in paraffin section: 1:50-200. Enzyme-linked Immunosorbent Assay: 1:100-200. Optimal working dilutions must be determined by end user.

ncbi gi num :

765330

ncbi acc num :

AAC60642.1

uniprot acc num :

P35318

ncbi mol weight :

20,420 Da

ncbi pathways :

Calcitonin-like Ligand Receptors Pathway (106379); Class B/2 (Secretin Family Receptors) Pathway (106378); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); HIF-1-alpha Transcription Factor Network Pathway (138045); Myometrial Relaxation And Contraction Pathways (198759); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356)

ncbi summary :

The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]

uniprot summary :

ADM: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. Belongs to the adrenomedullin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 11p15.4. Cellular Component: extracellular space; cytoplasm; extracellular region. Molecular Function: protein binding; adrenomedullin receptor binding; hormone activity; receptor binding. Biological Process: developmental growth; blood circulation; positive regulation of apoptosis; heart development; response to glucocorticoid stimulus; response to lipopolysaccharide; female pregnancy; signal transduction; positive regulation of vasodilation; response to insulin stimulus; negative regulation of cell proliferation; elevation of cytosolic calcium ion concentration; cAMP-mediated signaling; cell-cell signaling; receptor internalization; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; response to wounding; vasculogenesis; regulation of the force of heart contraction; aging; hormone secretion; organ regeneration; progesterone biosynthetic process; androgen metabolic process; neurite regeneration; positive regulation of heart rate; negative regulation of vasoconstriction; odontogenesis of dentine-containing teeth; response to starvation; positive regulation of angiogenesis; G-protein coupled receptor internalization; neural tube closure; response to hypoxia; negative regulation of vascular permeability; cAMP biosynthetic process; response to cold

size1 :

0.02 mg

price1 :

135 USD

size2 :

0.1 mg

price2 :

230

size3 :

0.2 mg

price3 :

305

more info or order :

MyBioSource product webpage