Monoclonal Antibody to Tumor Protein, Translationally Controlled 1 (TPT1) | MyBioSource MBS2001293 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Monoclonal Antibody to Tumor Protein, Translationally Controlled 1 (TPT1)

catalog :

MBS2001293

quantity :

0.01 mg

price :

105 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[C1]

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot: Sample: Recombinant TPT1, Human.

product information

catalog number :

MBS2001293

products type :

Antibody

products full name :

Monoclonal Antibody to Tumor Protein, Translationally Controlled 1 (TPT1)

products short name :

[Tumor Protein, Translationally Controlled 1 (TPT1)]

other names :

[translationally-controlled tumor protein isoform 3; Translationally-controlled tumor protein; translationally-controlled tumor protein; tumor protein, translationally-controlled 1; Fortilin; Histamine-releasing factor; HRF; p23]

products gene name :

[TPT1]

other gene names :

[TPT1; TPT1; HRF; p02; p23; TCTP; TCTP; HRF]

clonality :

Monoclonal

isotype :

IgG1 Kappa

clone :

[C1]

host :

Mouse

purity :

Protein A + Protein G affinity chromatography

form :

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol

concentration :

1mg/ml

storage stability :

Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP).

app notes :

Western blotting: 0.5-2 ug/mL;1:500-2000. Immunohistochemistry: 5-20 ug/mL;1:50-200. Immunocytochemistry: 5-20 ug/mL;1:50-200. Optimal working dilutions must be determined by end user

image1 heading :

Western Blot (WB)

other info1 :

Organism Species: Homo sapiens (Human). Source: Monoclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant TPT1 (Met1~Cys172 (Accession # P13693)) expressed in E.coli

ncbi gi num :

555943820

ncbi acc num :

NP_001273202.1

ncbi gb acc num :

NM_001286273.1

uniprot acc num :

P13693

ncbi pathways :

PLK1 Signaling Events Pathway (138007)

ncbi summary :

This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

uniprot summary :

TPT1: a novel heat shock protein with antiapoptotic and chaperone-like activity. Its levels are highly regulated in response to various cellular stimuli and stresses. Downregulated in response to proapoptotic treatments that induce Ca(++) stress, in a PKR-dependent manner. Colocalizes with CHFR to the mitotic spindle. Appears to be involved in calcium binding and microtubule stabilization. Its exosomal secretion is induced following DNA damage. Interacts with MCL1 and STEAP3, a p53-inducible transmembrane protein that facilitates the exosomal secretion of TPT1. Secreted TPT1 acts as a histamine-releasing factor, participates in inflammatory responses by inducing the release of histamine, and may play a role in tumor reversion. May play a direct role in placental calcium transport. Phosphorylation by Plk may decrease its microtubule-stabilizing activity and promote microtubule dynamics following metaphase. Critical for peripheral T cell maintenance and TCR-mediated cell proliferation. Protein type: Calcium-binding; Microtubule-binding. Chromosomal Location of Human Ortholog: 13q14.13. Cellular Component: cytoplasm; cytosol; extracellular space; multivesicular body; nucleus; tubulin complex. Molecular Function: calcium ion binding; microtubule binding; protein binding; RNA binding. Biological Process: calcium ion transport; cell differentiation; cellular calcium ion homeostasis; negative regulation of apoptosis; regulation of apoptosis; response to virus

size1 :

0.01 mg

price1 :

105 USD

size2 :

0.02 mg

price2 :

110

size3 :

0.05 mg

price3 :

145

size4 :

0.1 mg

price4 :

185

size5 :

0.2 mg

price5 :

235

size6 :

1 mg

price6 :

540

more info or order :

MyBioSource product webpage