catalog number :
MBS2001266
products full name :
Monoclonal Antibody to Fatty Acid Binding Protein 1, Liver (FABP1)
products short name :
Fatty Acid Binding Protein 1, Liver (FABP1)
other names :
Fatty acid binding protein 1, liver; Fatty acid-binding protein, liver; fatty acid-binding protein, liver; fatty acid-binding protein 1; liver-type fatty acid-binding protein; fatty acid binding protein 1, liver; Fatty acid-binding protein 1; Liver-type fatty acid-binding protein
products gene name :
FABP1
other gene names :
FABP1; FABP1; FABPL; L-FABP; FABPL; L-FABP
uniprot entry name :
FABPL_HUMAN
sequence :
The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSGS-SFSGKYQLQ SQENFEAFMK AIGLPEELIQ KGKDIKGVSE IVQNGKHFKF TITAGSKVIQ NEFTVGEECE LETMTGEKVK TVVQLEGDNK LVTTFKNIKS VTELNGDIIT NTMTLGDIVF KRISKRI
specificity :
The antibody is a mouse monoclonal antibody raised against FABP1. It has been selected for its ability to recognize FABP1 in immunohistochemical staining and western blotting.
purity :
Affinity Chromatography
form :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
storage stability :
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
tested application :
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
app notes :
Western blotting: 1:100-400. Immunocytochemistry in formalin fixed cells: 1:100-500. Immunohistochemistry in formalin fixed frozen section: 1:100-500. Immunohistochemistry in paraffin section: 1:50-200. Enzyme-linked Immunosorbent Assay: 1:100-200
ncbi acc num :
AAH32801.1
ncbi mol weight :
14,208 Da
ncbi pathways :
Fat Digestion And Absorption Pathway (194385); Fat Digestion And Absorption Pathway (194324); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); PPAR Signaling Pathway (83042); PPAR Signaling Pathway (450); PPARA Activates Gene Expression Pathway (530749); Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway (119544); Selenium Metabolism And Selenoproteins Pathway (198846)
ncbi summary :
This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Mar 2011]
uniprot summary :
FABP1: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. Protein type: Lipid-binding. Chromosomal Location of Human Ortholog: 2p11. Cellular Component: nucleoplasm; peroxisomal matrix; apical cortex; cytosol. Molecular Function: antioxidant activity; bile acid binding; phospholipid binding; chromatin binding; drug binding; long-chain fatty acid transporter activity; fatty acid binding. Biological Process: long-chain fatty acid transport; positive regulation of hydrolase activity; positive regulation of cell proliferation; cellular lipid metabolic process; negative regulation of caspase activity; intestinal absorption; positive regulation of fatty acid beta-oxidation; negative regulation of apoptosis