antibody

Cellubrevin antibody (clone k2A2)

MBS200122

0.05 ml

240 USD

monoclonal

mouse

nonconjugated

k2A2

human, mouse

western blot, ELISA, enzyme immunoassay

Antibody

Cellubrevin antibody (clone k2A2)

Cellubrevin

Vesicle-associated membrane protein 3; VAMP 3; CEB; Synaptobrevin-3; Cellubrevin; Synaptobrevin 3; VAMP3; Vesicle associated membrane protein 3.

vesicle-associated membrane protein 3; Vesicle-associated membrane protein 3; vesicle-associated membrane protein 3; VAMP-3; cellubrevin; synaptobrevin-3; vesicle-associated membrane protein 3; Cellubrevin; CEB; Synaptobrevin-3

VAMP3; VAMP3; CEB; SYB3; VAMP-3; CEB

VAMP3_HUMAN

Monoclonal

IgG2b, k

k2A2

Mouse

Human, Mouse

100

By protein-G affinity chromatography

Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

1mg/ml

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

ELISA (EIA), Western Blot (WB) (Tissue)

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000 ~ 2,000. Recommended starting dilution is 1:1,000.

Antigen Species: Human. Clone: Anti-human VAMP3 mAb, clone k2A2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human cellubrevin protein. Immunogen: Recombinant human cellubrevin (1-77aa) purified from E Coli

Neuroscience

Cellubrevin, also known as VAMP3, is a member of the Vamp/synaptobrevin family. Vamps, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. Cellubrevin is a vesicular soluble N-ethylmaleimide sensitive factor attachment protein receptor (v-SNARE) homologous to the neuronal synaptobrevins 1/2 and is also a substrate of tetanus neurotoxin.

Proux-G V., et al. (2005) Proc Natl Acad Sci USA. 102(18):6362-6367 Randhawa Vk., et al. (2000) Mol Cell Biol. 11(7):2403-2417 Olson AL., et al. (1997) Mol Cell Biol. 17(5):2425-2435

4759300

NP_004772

NM_004781.3

11,309 Da

Arf6 Trafficking Events Pathway 137954!!Phagosome Pathway 153910!!Phagosome Pathway 153859!!SNARE Interactions In Vesicular Transport Pathway 83057!!SNARE Interactions In Vesicular Transport Pathway 467

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]

0.05 ml

240 USD