FABP4 antibody (clone 3F4) | MyBioSource MBS200120 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FABP4 antibody (clone 3F4)

catalog :

MBS200120

quantity :

0.05 mL

price :

240 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3F4

reactivity :

human, mouse

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS200120

products type :

Antibody

products full name :

FABP4 antibody (clone 3F4)

products short name :

FABP4

products name syn :

Fatty acid binding protein 4; fatty acid binding protein 4 adipocyte; A-FABP; aP2

other names :

fatty acid-binding protein, adipocyte; Fatty acid-binding protein, adipocyte; fatty acid-binding protein, adipocyte; adipocyte lipid-binding protein; adipocyte-type fatty acid-binding protein; epididymis secretory protein Li 104; fatty acid-binding protein 4; fatty acid binding protein 4, adipocyte; Adipocyte lipid-binding protein; ALBP; Adipocyte-type fatty acid-binding protein; A-FABP; AFABP; Fatty acid-binding protein 4

products gene name :

FABP4

other gene names :

FABP4; FABP4; aP2; ALBP; AFABP; A-FABP; HEL-S-104; ALBP; A-FABP; AFABP

uniprot entry name :

FABP4_HUMAN

clonality :

Monoclonal

isotype :

IgG1, k

clone :

3F4

host :

Mouse

reactivity :

Human, Mouse

sequence length :

132

purity :

By protein-G affinity chromatography

form :

Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

concentration :

1mg/ml

storage stability :

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

tested application :

ELISA (EIA), Western Blot (WB) (Tissue)

app notes :

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000. Recommended starting dilution is 1:500.

other info1 :

Antigen Species: Human. Clone: Anti-human FABP4 mAb, clone 3F4, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human FABP4 protein. Immunogen: Recombinant human FABP4 (1-132aa) purified from E Coli

products categories :

Enzymes & Proteases

products description :

FABP4 (Fatty acid binding protein 4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. FABP4 is thought to regulate fatty acid uptake, release, and storage in adipocytes and participates in systemic glucose homeostasis and in macrophage responses in atherosclerosis. Blocking this protein either through genetic engineering or drugs has the possibility of treating heart disease, diabetes, asthma, obesity, and fatty liver disease.

products references :

Furuhashi M., et al., (2007) Nature. 21;447(7147):959-65 Shum BO, et al., (2006) J Clin Invest. 116(8):2183-92

ncbi gi num :

4557579

ncbi acc num :

NP_001433

ncbi gb acc num :

NM_001442.2

ncbi mol weight :

14,719 Da

ncbi pathways :

Developmental Biology Pathway (477129); Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway (106121); Lipid Digestion, Mobilization, And Transport Pathway (106111); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); PPAR Signaling Pathway (83042); PPAR Signaling Pathway (450); Transcriptional Regulation Of White Adipocyte Differentiation Pathway (205243)

ncbi summary :

FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]

uniprot summary :

FABP4: a lipid transport protein that is the predominant fatty acid binding protein found in adipocytes. Also expressed in macrophages. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. Homodimer. Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Interacts with PPARG. Monomer. FABP4 knockout mice fed a high-fat and high-calorie diet become obese but develop neither insulin resistance nor diabetes, suggesting that this protein might be a link between obesity and insulin resistance and diabetes. Mice deficient in both FABP4 and ApoE show protection against atherosclerosis when compared with mice deficient only in ApoE. Mice carrying a FABP4 genetic variant exhibit both reduced FABP4 expression and a reduced potential for developing type 2 diabetes and coronary heart disease. A related study in humans indicated a similar pattern, suggesting that FABP4 may be a potential therapeutic target in the treatment of these disorders. Belongs to the calycin superfamily,fatty-acid binding protein (FABP) family. Protein type: Lipid-binding. Chromosomal Location of Human Ortholog: 8q21. Cellular Component: cytoplasm; lipid particle; nucleus. Molecular Function: transporter activity; fatty acid binding. Biological Process: cholesterol homeostasis; transport; white fat cell differentiation; triacylglycerol catabolic process; brown fat cell differentiation; cytokine production; negative regulation of protein kinase activity; negative regulation of transcription, DNA-dependent; positive regulation of inflammatory response

size1 :

0.05 mL

price1 :

240 USD

size2 :

0.1 mL

price2 :

315

more info or order :

MyBioSource product webpage