TREM2 antibody (clone 2B5) | MyBioSource MBS200117 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

TREM2 antibody (clone 2B5)

catalog :

MBS200117

quantity :

0.05 mL

price :

240 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2B5

reactivity :

human, mouse

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS200117

products type :

Antibody

products full name :

TREM2 antibody (clone 2B5)

products short name :

TREM2

products name syn :

triggering receptor expressed on myeloid cells 2 isoform 1; triggering receptor expressed on myeloid cells 2; triggering receptor expressed on myeloid cells 2a; TREM-2; Trem2a; Trem2b; Trem2c

other names :

triggering receptor expressed on myeloid cells 2 isoform 1; Triggering receptor expressed on myeloid cells 2; triggering receptor expressed on myeloid cells 2; triggering receptor expressed on monocytes 2; triggering receptor expressed on myeloid cells 2a; triggering receptor expressed on myeloid cells 2; Triggering receptor expressed on monocytes 2

products gene name :

TREM2

other gene names :

TREM2; TREM2; TREM-2; Trem2a; Trem2b; Trem2c; TREM-2

uniprot entry name :

TREM2_HUMAN

clonality :

Monoclonal

isotype :

Mouse IgG3 heavy chain and k light chain

clone :

2B5

host :

Mouse

reactivity :

Human, Mouse

sequence length :

230

purity :

By protein-G affinity chromatography

form :

Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol.

concentration :

1mg/ml

storage stability :

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

tested application :

ELISA (EIA), Western Blot (WB) (Tissue, Cell lysate)

app notes :

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000. Recommended starting dilution is 1:500.

other info1 :

Antigen Species: Human. Clone: Anti-human TREM2 mAb, clone 2B5, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TREM2 protein. Immunogen: Recombinant human TREM2 (19-161aa) purified from E Coli

products categories :

Immunology

products description :

The triggering receptor expressed on myeloid cells-2 (TREM2) is a membrane protein that interacts with the TYROBP protein. The TREM2 and TYROBP proteins form a complex that transmits chemical signals to activate the cell. This complex is involved in the growth and development of several types of immune cells, particularly dendritic cells and activates these cells, triggering an inflammatory response to injury or disease. And the TYROBP-TREM2 complex also activates cells in the skeletal system and in the brain and spinal cord (central nervous system).

products references :

N'Diaye EN, et al., (2009) J Cell Biol. 184(2):215-23 Piccio L, et al., (2008) Brain. 131(11):3081-91

ncbi gi num :

9507203

ncbi acc num :

NP_061838

ncbi gb acc num :

NM_018965.3

ncbi mol weight :

24,669 Da

ncbi pathways :

Axon Guidance Pathway (105688); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Developmental Biology Pathway (477129); Immune System Pathway (106386); Innate Immune System Pathway (106387); Osteoclast Differentiation Pathway (193147); Osteoclast Differentiation Pathway (193096); Other Semaphorin Interactions Pathway (119526); Semaphorin Interactions Pathway (119519)

ncbi summary :

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

uniprot summary :

TREM2: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 6p21.1. Cellular Component: intracellular membrane-bound organelle; extracellular region; integral to membrane; plasma membrane. Molecular Function: peptidoglycan binding; lipopolysaccharide binding; receptor activity. Biological Process: axon guidance; positive regulation of peptidyl-tyrosine phosphorylation; detection of lipopolysaccharide; detection of peptidoglycan; innate immune response; positive regulation of calcium-mediated signaling; humoral immune response; positive regulation of antigen processing and presentation of peptide antigen via MHC class II. Disease: Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

size1 :

0.05 mL

price1 :

240 USD

size2 :

0.1 mL

price2 :

315

more info or order :

MyBioSource product webpage