Monoclonal anti-human Hsp105 alpha antibody (clone J1G12) | MyBioSource MBS200090 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Monoclonal anti-human Hsp105 alpha antibody (clone J1G12)

catalog :

MBS200090

quantity :

0.05 mL

price :

240 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

J1G12

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS200090

products type :

Antibody

products full name :

Monoclonal anti-human Hsp105 alpha antibody (clone J1G12)

products short name :

HSP105alpha

products name syn :

HSPH1; Heat shock 105kDa/110kDa protein 1; HSP105alpha; HSP105-alpha; Heat shock 105kDa/110kDa protein 1 Antigen NY CO 25; DKFZp686M05240; Heat shock 105kD; Heat shock 105kD alpha; Heat shock 105kD beta; Heat shock 105kDa protein; Heat shock 105kDa protein 1; Heat shock 110kDa protein; Heat shock protein 105 kDa; HSP105A; HSP105B; HSP110; HSPH 1; KIAA0201; NY CO 25.

other names :

heat shock protein 105 kDa isoform 1; Heat shock protein 105 kDa; heat shock protein 105 kDa; antigen NY-CO-25; heat shock 105kD alpha; heat shock 105kD beta; heat shock 105kDa/110kDa protein 1; Antigen NY-CO-25; Heat shock 110 kDa protein

products gene name :

HSP105alpha

other gene names :

HSPH1; HSPH1; HSP105; HSP105A; HSP105B; NY-CO-25; HSP105; HSP110; KIAA0201

uniprot entry name :

HS105_HUMAN

clonality :

Monoclonal

isotype :

IgG2b, k

clone :

J1G12

host :

Mouse

reactivity :

Human

sequence length :

858

purity :

By protein-G affinity chromatography

form :

Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium azide, 10% Glycerol.

concentration :

1mg/ml

storage stability :

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000 ~ 2,000. Recommended starting dilution is 1:1,000.

other info1 :

Antigen Species: Human. Clone: Anti-human Hsp105 alpha mAb, clone J1G12, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Hsp105 alpha protein. Immunogen: Recombinant human Hsp105 alpha (1-858aa) purified from E Coli

products categories :

Heat Shock Proteins

products description :

Hsp105 is a mammalian member of the HSP105/110 family, a diverged subgroup of the HSP70 family. HSP105 exists as two isoforms, alpha and beta. Hsp105 alpha associates with Hsp70/Hsc70 as complexes in vivo and regulates the chaperone activity of Hsp70/Hsc70 negatively in vitro and in vivo. Hsp105 alpha is constitutively expressed and also induced by various stress, whereas Hsp105beta, lacking 44 amino acids from Hsp105 alpha, is specifically expressed during mild heat shock. Although Hsp105 alpha is shown to localize in the cytoplasm of mammalian cells, cellular localization of Hsp105beta is not known

products references :

Wang XY., et al. (2001) J Immunol. 166(1):490-7. Yamagishi N., et al. (2006) Exp Cell Res. 312(17):3215-23. Saito Y., et al. (2007) Exp Cell Res. 313(17):3707-17.

ncbi gi num :

42544159

ncbi acc num :

NP_006635

ncbi gb acc num :

NM_006644.3

ncbi mol weight :

97,460 Da

ncbi pathways :

Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Protein Processing In Endoplasmic Reticulum Pathway (167325); Protein Processing In Endoplasmic Reticulum Pathway (167190); Scavenging By Class F Receptors Pathway (833816)

uniprot summary :

HSP105: a molecular chaperone of the heat shock protein 70 family. Has ATPase activity. Expressed at especially high levels in mammalian brain and has been shown to suppress apoptosis in neuronal cells and to prevent the aggregation of proteins following heat shock. Known to interact with a variety of proteins including alpha-tubulin and the androgen receptor. Two alternatively spliced isoforms have been described. Protein type: Heat shock protein; Chaperone. Chromosomal Location of Human Ortholog: 13q12.3. Cellular Component: nucleoplasm; microtubule; cytoplasm; extracellular region; cytosol. Molecular Function: protein binding; ATP binding; alpha-tubulin binding. Biological Process: receptor-mediated endocytosis; positive regulation of NK T cell activation; chaperone cofactor-dependent protein folding; positive regulation of MHC class I biosynthetic process; response to unfolded protein

size1 :

0.05 mL

price1 :

240 USD

size2 :

0.1 mL

price2 :

315

more info or order :

MyBioSource product webpage