CD44 antibody (clone 5C10) | MyBioSource MBS200089 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CD44 antibody (clone 5C10)

catalog :

MBS200089

quantity :

0.05 ml

price :

240 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5c10

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS200089

products type :

Antibody

products full name :

CD44 antibody (clone 5C10)

products short name :

CD44

products name syn :

CD44 antigen isoform 3 precursor; CD44 molecule (Indian blood group); MIC4; MDU2; MDU3; CD44 antigen (homing function and Indian blood group system); IN; MC56; Pgp1; CD44R; HCELL; CSPG8; hematopoietic cell E- and L-selectin ligand; chondroitin sulfate proteoglycan 8

other names :

CD44 antigen isoform 3; CD44 antigen; CD44 antigen; GP90 lymphocyte homing/adhesion receptor; Hermes antigen; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; epican; extracellular matrix receptor III; hematopoietic cell E- and L-selectin ligand; heparan sulfate proteoglycan; homing function and Indian blood group system; hyaluronate receptor; phagocytic glycoprotein 1; CD44 molecule (Indian blood group); CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD_antigen: CD44

products gene name :

CD44

other gene names :

CD44; CD44; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; LHR; MDU2; MDU3; MIC4; ECMR-III; PGP-1; PGP-I

uniprot entry name :

CD44_HUMAN

clonality :

Monoclonal

isotype :

IgG2b, k

clone :

5C10

host :

Mouse

reactivity :

Human

sequence length :

493

purity :

By protein-G affinity chromatography

form :

Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

concentration :

1mg/ml

storage stability :

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

tested application :

ELISA (EIA), Western Blot (WB) (Cell lysate)

app notes :

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000 ~ 2,000. Recommended starting dilution is 1:1,000.

other info1 :

Antigen Species: Human. Clone: Anti-human CD44 mAb, clone 5C10, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CD44 protein. Immunogen: Recombinant human CD44 (21-145aa) purified from E Coli

products categories :

Immunology

products description :

CD44 is a broadly distributed transmembrane glycoprotein that plays a critical role in a variety of cellular behaviors, including adhesion, migration, invasion, and survival. CD44 mediates cell-cell and cell-matrix interactions in a large part through its affinity for hyaluronan (HA), a glycosaminoglycan constituent of extracellular matrices, but also potentially through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Variants of CD44 are expressed in tissues during development, including embryonic epithelia. known functions of CD44 are cellular adhesion (aggregation and migration), hyaluronate degradation, lymphocyte activation, lymph node homing, myelopoiesis and lymphopoiesis, angiogenesis, and release of cytokines. The functions of CD44 are principally dependant on cellular adhesion in one setting or another

products references :

Cichy, J. and Pure, E. (2003) J.Cell Biol. 161, 839-843 Sneath RJ, Mangham DC (1998) Mol Pathol. 51(4):191-200

ncbi gi num :

48255939

ncbi acc num :

NP_001001390

ncbi gb acc num :

NM_001001390.1

ncbi mol weight :

15,635 Da

ncbi pathways :

Cell Surface Interactions At The Vascular Wall Pathway 106062!!Cytokine Signaling In Immune System Pathway 366171!!Defective B3GAT3 Causes JDSSDHD Pathway 1127588!!Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway 1127592!!Defective B4GALT7 Causes EDS, Progeroid Type Pathway 1127587!!Defective CHST14 Causes EDS, Musculocontractural Type Pathway 1127591!!Defective CHST3 Causes SEDCJD Pathway 1127590!!Defective CHST6 Causes MCDC1 Pathway 1127593!!Defective CHSY1 Causes TPBS Pathway 1127589!!Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway 1127594

ncbi summary :

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

size :

0.05 ml

price :

240 USD

more info or order :

MyBioSource product webpage