PSMA antibody (clone k1H7) | MyBioSource MBS200082 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PSMA antibody (clone k1H7)

catalog :

MBS200082

quantity :

0.05 ml

price :

240 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

k1H7

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS200082

products type :

Antibody

products full name :

PSMA antibody (clone k1H7)

products short name :

PSMA

products name syn :

folate hydrolase (prostate-specific membrane antigen); FGCP; FOLH; GCP2; GCPII; mGCP; NAALAD1; NAALAdase; PSM; PSMA; glutamate carboxypeptidase 2 isoform 2

other names :

glutamate carboxypeptidase 2 isoform 2; Glutamate carboxypeptidase 2; glutamate carboxypeptidase 2; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; cell growth-inhibiting gene 27 protein; folylpoly-gamma-glutamate carboxypeptidase; glutamate carboxylase II; glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; prostate specific membrane antigen variant F; pteroylpoly-gamma-glutamate carboxypeptidase; folate hydrolase (prostate-specific membrane antigen) 1; Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; FGCP; Glutamate carboxypeptidase II; GCPII; Membrane glutamate carboxypeptidase; mGCP; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; Prostate-specific membrane antigen; PSM; PSMA; Pteroylpoly-gamma-glutamate carboxypeptidase

products gene name :

PSMA

other gene names :

FOLH1; FOLH1; PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase; FOLH; NAALAD1; PSM; PSMA; FGCP; GCPII; mGCP; NAALADase I; PSM; PSMA

uniprot entry name :

FOLH1_HUMAN

clonality :

Monoclonal

isotype :

IgG1, k

clone :

k1H7

host :

Mouse

reactivity :

Human

sequence length :

719

purity :

By protein-G affinity chromatography

form :

Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

concentration :

1mg/ml

storage stability :

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

tested application :

ELISA (EIA), Western Blot (WB) (Cell lysate)

app notes :

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000~ 2,000. Recommended starting dilution is 1:1,000.

other info1 :

Antigen Species: Human. Clone: Anti-human PSMA mAb, clone k1H7, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PSMA protein. Immunogen: Recombinant human PSMA (117-351aa) purified from E Coli

products categories :

Cancer

products description :

Prostate-specific membrane antigen (PSMA) is a 100-120 kDa type II transmembrane glycoprotein that is a glutamate-preferring carboxy-peptidase. Three functionally distinct proteins are encoded, including folylpoly-gamma-glutamate carboxypeptidase in the intestine, N-acetylated alpha-linked acidic dipeptidase 1 in the brain, and prostate-specific membrane antigen in the prostate. PSMA is highly expressed in prostate secretory-acinar epithelium, in some benign extraprostatic epithelial cells from breast, duodenum, and kidney tissues, and in prostate cancer.

products references :

Rajasekaran SA, et al., (2008) Mol Cancer Ther 7(7):2142-2151 Polly D.G, et al., (2005) Int J Cancer 116(3):415-421 Susan F.S, et al., (2005) Expert Opin Ther Targets 9(3):561-570

ncbi gi num :

62548858

ncbi acc num :

NP_001014986

ncbi gb acc num :

NM_001014986.1

ncbi mol weight :

50,090 Da

ncbi pathways :

Alanine, Aspartate And Glutamate Metabolism Pathway 101142!!Alanine, Aspartate And Glutamate Metabolism Pathway 100063!!Metabolic Pathways 132956!!One Carbon Metabolism Pathway 198756!!Vitamin Digestion And Absorption Pathway 199556!!Vitamin Digestion And Absorption Pathway 199538

ncbi summary :

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]

size :

0.05 ml

price :

240 USD

more info or order :

MyBioSource product webpage