HSP60 antibody (clone 2E4) | MyBioSource MBS200078 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

HSP60 antibody (clone 2E4)

catalog :

MBS200078

quantity :

0.05 ml

price :

240 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2.00E+04

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS200078

products type :

Antibody

products full name :

HSP60 antibody (clone 2E4)

products short name :

HSP60

products name syn :

CPN60; GroEL; HSP65; SPG13; HuCHA60; Heat shock 60kDa protein 1; HSP60; Heat shock 60kDa protein 1 60 kDa chaperonin; GroEL; E; coli; homolog of; 60 kDa heat shock protein mitochondrial; 60kDa; cb863; Chaperonin; Chaperonin 60; Chaperonin; 60-KD; CPN 60; fa04a05; fb22d10; fi27b05; GroEL Homolog; Heat shock 60kD protein 1 (chaperonin); Heat shock 60kD protein 1 chaperonin; heat shock 60kDa protein 1 (chaperonin); Heat shock protein 1 (chaperonin); Heat Shock Protein 60; Heat shock protein 65; HLD4; Hsp 60; HSP 65; HSPD 1; HSPD1; HuCHA60; id:ibd2197; Spastic paraplegia 13 Mitochondrial matrix protein P1; P60 lymphocyte protein; sb:cb144; Short heat shock protein 60 Hsp60s1; Spastic paraplegia 13 (autosomal dominant); SPG 13; wu:fa04a05; wu:fb22d10; wu:fi04a12; wu:fi27b05.

other names :

60 kDa heat shock protein, mitochondrial; 60 kDa heat shock protein, mitochondrial; 60 kDa heat shock protein, mitochondrial; 60 kDa chaperonin; P60 lymphocyte protein; chaperonin 60; heat shock protein 65; mitochondrial matrix protein P1; short heat shock protein 60 Hsp60s1; heat shock 60kDa protein 1 (chaperonin); 60 kDa chaperonin; Chaperonin 60; CPN60; Heat shock protein 60; HSP-60; Hsp60; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein

products gene name :

HSP60

other gene names :

HSPD1; HSPD1; HLD4; CPN60; GROEL; HSP60; HSP65; SPG13; HSP-60; HuCHA60; HSP60; CPN60; HSP-60; Hsp60

uniprot entry name :

CH60_HUMAN

clonality :

Monoclonal

isotype :

IgG1, k

clone :

2.00E+04

host :

Mouse

reactivity :

Human

sequence length :

573

purity :

By protein-G affinity chromatography

form :

Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

concentration :

1mg/ml

storage stability :

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

tested application :

ELISA (EIA), Western Blot (WB) (Cell lysate), Immunohistochemistry (IHC)

app notes :

The antibody has been tested by ELISA, Western blot and immunohistochemistry analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot is 1:1,000 ~ 1:2,000 and immunohistochemistry analysis is 1:50~100. Recommended starting dilution for Western blot is 1:1,000 and Immunohistochemistry is 1:50.

other info1 :

Antigen Species: Human. Clone: Anti-human Hsp60 mAb, clone 2E4, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Hsp60 protein. Immunogen: Recombinant human Hsp60 (1-573aa) purified from E Coli

products categories :

Heat Shock Proteins

products description :

Heat shock protein 60 (HSP60) is a mitochondrial chaperonin that is typically held responsible for the transportation and refolding of proteins from the cytoplasm into the mitochondrial matrix. HSP60 is the ~60kDa mammalian equivalent to GroEL of E.coli. Process of HSP60 is regulated by the cochaperonin HSP10, a single heptameric ring of ~10kD subunits that forms a complex with HSP60. HSP10 coordinates the ATPase activity of the HSP60 subunits to allow the release of bound polypeptide in a manner productive for folding.

products references :

Cheng MY, et al., (1990) Nature. 348:455-8 Ghosh JC, et al., (2008) J Biol Chem. 283(8):5188-94

ncbi gi num :

31542947

ncbi acc num :

NP_002147

ncbi gb acc num :

NM_002156.4

ncbi mol weight :

17,100 Da

ncbi pathways :

Legionellosis Pathway 469200!!Legionellosis Pathway 469186!!Metabolism Of Proteins Pathway 106230!!Mitochondrial Protein Import Pathway 576261!!RNA Degradation Pathway 117291!!RNA Degradation Pathway 116127!!SIDS Susceptibility Pathways 198901!!Tuberculosis Pathway 213780!!Tuberculosis Pathway 213743!!Type I Diabetes Mellitus Pathway 83095

ncbi summary :

This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]

size :

0.05 ml

price :

240 USD

more info or order :

MyBioSource product webpage