catalog number :
MBS200077
products full name :
IRF7 antibody (clone 3D9)
products short name :
IRF7
products name syn :
interferon regulatory factor 7 isoform a; interferon regulatory factor 7; irf-7; IRF7A; IRF-7H
other names :
interferon regulatory factor 7 isoform a; Interferon regulatory factor 7; interferon regulatory factor 7; IRF-7; interferon regulatory factor-7H; interferon regulatory factor 7
products gene name :
IRF7
other gene names :
IRF7; IRF7; IRF7A; IRF7B; IRF7C; IRF7H; IRF-7H; IRF-7
uniprot entry name :
IRF7_HUMAN
purity :
By protein-G affinity chromatography
form :
Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.
storage stability :
Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.
tested application :
ELISA (EIA), Western Blot (WB) (Cell lysate)
app notes :
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000~ 2,000. Recommended starting dilution is 1:1,000.
other info1 :
Antigen Species: Human. Clone: Anti-human IRF-7 mAb, clone 3D9, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human IRF-7 protein. Immunogen: Recombinant human IRF-7 (1-150aa) purified from E Coli
products categories :
Hormones & Cytokines
products description :
Interferon regulatory factor (IRF) 7 is a member of the interferon regulatory transcription factor family. IRF7 plays an essential role in virus-activated transcription of type I interferon alpha genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.
products references :
Arun P, et al., (2006) Biochem Biophys Res Commun 342(1):50-56 Honda k, et al., (2005) Nature 434(7034):772-777 Au W.C, et al.,(2001) Virology 280(2):273-282
ncbi gb acc num :
NM_001572.3
ncbi mol weight :
55,635 Da
ncbi pathways :
Activated TLR4 Signalling Pathway 106400!!Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway 187088!!Apoptosis Pathway 198797!!Cytokine Signaling In Immune System Pathway 366171!!Cytosolic DNA-sensing Pathway 125137!!Cytosolic DNA-sensing Pathway 124833!!Cytosolic Sensors Of Pathogen-associated DNA Pathway 576255!!DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway 833822!!Factors Involved In Megakaryocyte Development And Platelet Production Pathway 187196!!Hemostasis Pathway 106028
ncbi summary :
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]