antibody

SNAP25 antibody (clone 4E11)

MBS200064

0.05 ml

240 USD

monoclonal

mouse

nonconjugated

4.00E+11

human, mouse

western blot, ELISA, enzyme immunoassay

Antibody

SNAP25 antibody (clone 4E11)

SNAP25

SNAP25; SNAP; SNAP25; Synaptosomal-associated protein; His- tag; SNAP-25; Synaptosomal-associated 25 kDa protein; Super protein; SuP; Synaptosomal-associated protein 25; Synaptosomal-associated protein 25 isoform SNAP25B bA416N4.2; Bdr; dJ1068F16.2; FLJ23079; HGNC:11132; MGC105414; MGC139754; Resistance to inhibitors of cholinesterase 4 homolog; RIC 4; RIC4; SEC9; SNAP 25; SNAP-25B; SNP 25; sp; Synaptosomal associated 25 kDa protein; Synaptosomal associated protein; Synaptosomal Associated Protein 25; Synaptosomal associated protein 25kDa.

synaptosomal-associated protein 25 isoform SNAP25B; Synaptosomal-associated protein 25; synaptosomal-associated protein 25; SUP; resistance to inhibitors of cholinesterase 4 homolog; super protein; synaptosomal-associated protein, 25kD; synaptosomal-associated protein, 25kDa; Super protein; SUP; Synaptosomal-associated 25 kDa protein

SNAP25

SNAP25; SNAP25; RIC4; SEC9; SNAP; RIC-4; SNAP-25; bA416N4.2; dJ1068F16.2; SNAP; SNAP-25; SUP

SNP25_HUMAN

Monoclonal

IgG1, k

4.00E+11

Mouse

Human, Mouse

206

By protein-G affinity chromatography

Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

1mg/ml

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

ELISA (EIA), Western Blot (WB) (Cell lysate)

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000 ~ 3,000. Recommended starting dilution is 1:2,000.

Antigen Species: Human. Clone: Anti-human SNAP25 mAb, clone 4E11, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human SNAP25 protein. Immunogen: Recombinant human SNAP25 (1-206aa) purified from E Coli

Neuroscience

The synaptosomal-associated protein (SNAP25) is an essential component of the core complex that mediates presynaptic vesicle trafficking. Thus, SNAP25 is directly involved in the release of neurotransmitters.

Schulz JR et al., (1998) J Biol Chem 273(38):24355-9 Tafoya LC et al., (2006) J Neurosci 26(30):7826-38

18765735

NP_570824

NM_130811.2

23,336 Da

Acetylcholine Neurotransmitter Release Cycle Pathway 106525!!Disease Pathway 530764!!Dopamine Neurotransmitter Release Cycle Pathway 106523!!Effects Of Botulinum Toxin Pathway 138028!!GABA Synthesis, Release, Reuptake And Degradation Pathway 187174!!Glutamate Neurotransmitter Release Cycle Pathway 106522!!Insulin Signaling Pathway 198845!!Insulin Secretion Pathway 777534!!Integration Of Energy Metabolism Pathway 106096!!Metabolism Pathway 477135

Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

0.05 ml

240 USD