catalog number :
MBS200060
products full name :
PGP9.5 antibody (clone 3D9)
products short name :
PGP9.5
products name syn :
uCHL1; PGP9.5; 1-223aa; uCH-L1; EC 3.4.19.12; ubiquitin thioesterase L1; Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin carboxyl-terminal esterase L1 Gracile axonal dystrophy; Neuron cytoplasmic protein 9.5; Park 5; Parkinson Disease 5; PGP95; uCH L1; Protein gene product 9.5; ubiquitin C terminal esterase L1; ubiquitin C terminal hydrolase (neuron specific); ubiquitin carboxyl terminal esterase L1; ubiquitin carboxyl terminal hydrolase isozyme L1; ubiquitin thiolesterase; ubiquitin thiolesterase L1.
products gene name :
PGP9.5
reactivity :
Human, Mouse
purity :
By protein-G affinity chromatography
form :
Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.
storage stability :
Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.
tested application :
ELISA (EIA), Western Blot (WB) (Cell lysate), Immunohistochemistry (IHC)
app notes :
The antibody has been tested by ELISA, Western blot and immunohistochemistry analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot is 1:500 ~ 1:2,000 and immunohistochemistry analysis is 1:100~200. Recommended starting dilution for Western blot is 1:1,000 and Immunohistochemistry is 1:100.
other info1 :
Antigen Species: Human. Clone: Anti-human PGP9.5 mAb, clone 3D9, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PGP9.5 protein. Immunogen: Recombinant human PGP9.5 (1-223aa) purified from E Coli
products categories :
Ubiquitination
products description :
PGP9.5/UCH-L1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. PGP9.5 is a component of the ubiquitin system, which has a fundamental role in regulating various biological activities. PGP9.5 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.
products references :
kenji H et al, (1999) Am J Pathol 155(3):711-715 Liu Y et al, (2002) Cell 111(2):209-18 Mikako Sakurai.et al, (2006) Cell 119:162-171
ncbi acc num :
AAB46870.1
ncbi gb acc num :
NM_004181