PSP antibody (clone 3G12) | MyBioSource MBS200048 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PSP antibody (clone 3G12)

catalog :

MBS200048

quantity :

0.05 mL

price :

240 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3G12

reactivity :

human, mouse

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS200048

products type :

Antibody

products full name :

PSP antibody (clone 3G12)

products short name :

PSP

products name syn :

PSPH; Phosphoserine phosphatase Human; PSPase; PSP; EC 3.1.3.3; O-phosphoserine phosphohydrolase; L-3-phosphoserine phosphatase; Phosphoserine phosphatase; L 3 phosphoserine phosphatase; O phosphoserine phosphohydrolase; Phosphoserine phosphatase deficiency; included

other names :

phosphoserine phosphatase; Phosphoserine phosphatase; phosphoserine phosphatase; L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase; PSPase; phosphoserine phosphatase; L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase

products gene name :

PSP

other gene names :

PSPH; PSPH; PSP; PSPHD; PSP; PSPase

uniprot entry name :

SERB_HUMAN

clonality :

Monoclonal

isotype :

IgG1, k

clone :

3G12

host :

Mouse

reactivity :

Human, Mouse

sequence length :

225

purity :

By protein-G affinity chromatography

form :

Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

concentration :

1mg/ml

storage stability :

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

tested application :

ELISA (EIA), Western Blot (WB) (Cell lysate)

app notes :

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000 ~ 2,000. Recommended starting dilution is 1:1,000.

other info1 :

Antigen Species: Human. Clone: Anti-human PSP mAb, clone 3G12, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PSP protein. Immunogen: Recombinant human PSP (1-225aa) purified from E Coli

products categories :

Enzymes & Proteases

products description :

Human phosphoserine phosphatase (HPSP), specific for D- and L- phosphoserine, has been identified in all human tissues. HPSP is a Mg(2+)-dependent phosphoserine phosphatase. The three dimensional structure of HPSP reveals the structural and functional role of the divalent cation in the active site of phosphatases. In particular, the complex structures reveal that the open-closed environmental change of the active site, generated by local rearrangement of the alpha-helical bundle domain, is important for the substrate recognition and hydrolysis.

products references :

Moro-Furlani, et al., (1980) Ann Hum Genet 43(4):323-3233 kim HY, et al., (2002) J Biol Chem 277(48):46651-46658 Peeraer Y, et al., (2004) Eur J Biochem 271(16):3421-3427

ncbi gi num :

46249388

ncbi acc num :

NP_004568

ncbi gb acc num :

NM_004577.3

ncbi mol weight :

25,008 Da

ncbi pathways :

Amino Acid Synthesis And Interconversion (transamination) Pathway (106173); Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567); Glycine, Serine And Threonine Metabolism Pathway (82949); Glycine, Serine And Threonine Metabolism Pathway (313); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169)

ncbi summary :

The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq, Jul 2008]

uniprot summary :

PSPH: Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:614023]. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome. Belongs to the SerB family. Protein type: EC 3.1.3.3; Hydrolase; Amino Acid Metabolism - glycine, serine and threonine; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 7p11.2. Cellular Component: neuron projection; cytoplasm; cytosol. Molecular Function: protein homodimerization activity; phosphoserine phosphatase activity; magnesium ion binding; calcium ion binding. Biological Process: response to nutrient levels; L-serine biosynthetic process; dephosphorylation; response to mechanical stimulus; L-serine metabolic process; amino acid biosynthetic process; response to testosterone stimulus. Disease: Phosphoserine Phosphatase Deficiency

size1 :

0.05 mL

price1 :

240 USD

size2 :

0.1 mL

price2 :

315

more info or order :

MyBioSource product webpage