catalog number :
MBS200041
products full name :
PkCk2 antibody (clone 3G1)
products short name :
PkCk2
products name syn :
CSNK2A1; CK2A1; Protein kinase Casein Kinase 2 alpha; PKCK2; CK II; EC 2.7.11.1; Casein kinase II subunit alpha; Casein kinase II alpha 1 subunit isoform a Casein kinase 2 alpha 1 polypeptide; Casein kinase II alpha 1 subunit; Casein kinase II alpha subunit; CK II; CK2 alpha; CK2 catalytic subunit alpha; CK2A1; CKII.
other names :
casein kinase II subunit alpha isoform a; Casein kinase II subunit alpha; casein kinase II subunit alpha; CK II alpha 3; CK2 catalytic subunit alpha; casein kinase II alpha 1 polypeptide pseudogene; casein kinase II alpha 1 subunit; protein kinase CK2; casein kinase 2, alpha 1 polypeptide
products gene name :
PkCk2
other gene names :
CSNK2A1; CSNK2A1; CKII; CK2A1; CSNK2A3; CK2A1; CK II alpha
uniprot entry name :
CSK21_HUMAN
purity :
By protein-G affinity chromatography
form :
Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.
storage stability :
Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.
tested application :
ELISA (EIA), Western Blot (WB) (Cell lysate)
app notes :
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 2,000. Recommended starting dilution is 1:1,000.
other info1 :
Antigen Species: Human. Clone: Anti-human PkCk-2 mAb, clone 3G1, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PkCk-2 protein. Immunogen: Recombinant human PkCk-2 (1-391aa) purified from E Coli
products categories :
Signal Transduction
products description :
Protein kinase Casein kinase 2 (PkCk-2) is a ubiquitous Ser/Thr kinase expressed in all eukaryotes. It phosphorylates a number of proteins involved in various cellular processes. PkCk-2 holoenzyme is catalytically active tetramer, composed of two homologous or identical and constitutively active catalytic (alpha) and two identical regulatory (beta) subunits.
products references :
Landesman-Bollag E et al., (2001) Oncogene 20:3247-3257 Nambudiry R et al., (2003) BMC Struct Biol 3:4 Lars P k et al., (2004) FEBS Lett 569:217-223
ncbi gb acc num :
NM_001895.3
ncbi mol weight :
29,181 Da
ncbi pathways :
Adherens Junction Pathway 83070!!Adherens Junction Pathway 481!!Alpha-synuclein Signaling Pathway 137913!!Axon Guidance Pathway 105688!!BCR Signaling Pathway 138058!!BDNF Signaling Pathway 712093!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!Condensation Of Prometaphase Chromosomes Pathway 730316!!Developmental Biology Pathway 477129
ncbi summary :
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014]