This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
TLR2 antibody (clone 1F10)
catalog :
MBS200036
quantity :
0.05 ml
price :
240 USD
clonality :
monoclonal
host :
mouse
reactivity :
human
application :
western blot, ELISA, enzyme immunoassay
product information
catalog number :
MBS200036
products type :
Antibody
products full name :
TLR2 antibody (clone 1F10)
products short name :
TLR2
products name syn :
toll-like receptor 2; TIL4; CD282; til 4
other names :
toll-like receptor 2; Toll-like receptor 2; toll-like receptor 2; toll/interleukin 1 receptor-like 4; toll/interleukin-1 receptor-like protein 4; toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; CD_antigen: CD282
products gene name :
TLR2
other gene names :
TLR2; TLR2; TIL4; CD282; TIL4
uniprot entry name :
TLR2_HUMAN
clonality :
Monoclonal
isotype :
IgG1, k
clone :
1F10
host :
Mouse
reactivity :
Human
sequence length :
784
purity :
By protein-G affinity chromatography
form :
Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.
concentration :
1mg/ml
storage stability :
Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.
tested application :
ELISA (EIA), Western Blot (WB) (Cell lysate)
app notes :
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000. Recommended starting dilution is 1:500.
other info1 :
Antigen Species: Human. Clone: Anti-human TLR2 mAb, clone 1F10, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TLR2 protein. Immunogen: Recombinant human TLR2 (221-384aa) purified from E Coli
products categories :
Immunology
products description :
Toll-like receptor 2 (TLR2) has been shown to mediate the innate immune response to ligands derived from a variety of pathogens, including Gram-positive bacteria, Mycoplasma, yeasts, and parasites. TLR2 is a signalling receptor that is activated by LPS in a response that depends on LPS-binding protein and is enhanced by CD14. A region in the intracellular domain of TLR2 with homology to a portion of the interleukin (IL)-1 receptor that is implicated in the activation of the IL-1-receptor-associated kinase is required for this response
products references :
Aliprantis AO et al. (1999) Science 285:736-739. Matsuguchi T et al., (2000) J Immunol. 165(10): 5767-5772. Takeda k et al., (2003) annurev. Immunol. 21:335-376. Janeway, C. A. et al., (2002) annurev. Immunol. 20:197 Yang RB, et al., (1998) Nature 395(6699) 284-288
ncbi gi num :
19718734
ncbi acc num :
NP_003255
ncbi gb acc num :
NM_003264.3
ncbi mol weight :
89,838 Da
ncbi pathways :
Activated TLR4 Signalling Pathway 106400!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Beta Defensins Pathway 530759!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Defensins Pathway 530757!!Hepatitis B Pathway 694606!!Herpes Simplex Infection Pathway 377873!!Herpes Simplex Infection Pathway 377865
ncbi summary :
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008]
size :
0.05 ml
price :
240 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!