PEDF antibody (clone 1C4) | MyBioSource MBS200032 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

PEDF antibody (clone 1C4)

catalog :

MBS200032

quantity :

0.05 mL

price :

240 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1C4

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

product information

catalog number :

MBS200032

products type :

Antibody

products full name :

PEDF antibody (clone 1C4)

products short name :

PEDF

products name syn :

Pigment epithelium-derived factor; EPC-1; PIG35; SERPINF1; Pigment epithelium-derived factor EPC 1; EPC1; PIG 35; Pigment epithelium derived factor; Proliferation inducing protein 35; SERPIN F1; Serpin peptidase inhibitor clade F member 1; SERPINF 1

other names :

pigment epithelium-derived factor; Pigment epithelium-derived factor; pigment epithelium-derived factor; cell proliferation-inducing gene 35 protein; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; serpin F1; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; Cell proliferation-inducing gene 35 protein; EPC-1; Serpin F1

products gene name :

PEDF

other gene names :

SERPINF1; SERPINF1; OI6; OI12; PEDF; EPC-1; PIG35; PEDF; PEDF

uniprot entry name :

PEDF_HUMAN

clonality :

Monoclonal

isotype :

IgG1, k

clone :

1C4

host :

Mouse

reactivity :

Human

sequence length :

418

purity :

By protein-G affinity chromatography

form :

Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

concentration :

1mg/ml

storage stability :

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

tested application :

ELISA (EIA), Western Blot (WB) (Cell lysate)

app notes :

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 2,000. Recommended starting dilution is 1:1,000.

other info1 :

Antigen Species: Human. Clone: Anti-human PEDF mAb, clone 1C4, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PEDF protein. Immunogen: Recombinant human PEDF (19-418 aa) purified from E Coli

products categories :

Hormones & Cytokines

products description :

Pigment epithelium-derived factor (PEDF) is a 50kDa glycoprotein and member of the serpin superfamily without any activity of serine protease. PEDF is an angiogenesis inhibitor with neurotrophic properties, balances angiogenesis in the eye and blocks tumor progression. That is, in neuronal cell, PEDF is promoting cell survival and differentiation, however, when endothelial cells are exposed to PEDF, their cell migration and proliferation are inhibited, and they undergo apoptosis.

products references :

Baba H. et al (2005) Arteriosler Thromb Vasc Biol. 25, 1938-1944 Filleur S. et al (2005) Cancer Res. 65, 5144-5152 Hattenbach LO. et al (2004) Ophthalmic Res. 37, 341-346

ncbi gi num :

39725934

ncbi acc num :

NP_002606

ncbi gb acc num :

NM_002615.5

ncbi mol weight :

46,312 Da

ncbi summary :

The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]

uniprot summary :

PEDF: a secreted neurotrophic protein that induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity. Extracellular phosphorylation enhances antiangiogenic activity. Protein type: Secreted, signal peptide; Inhibitor; Secreted. Chromosomal Location of Human Ortholog: 17p13.3. Cellular Component: axon hillock; extracellular matrix; extracellular space; perinuclear region of cytoplasm; melanosome; extracellular region; basement membrane. Molecular Function: serine-type endopeptidase inhibitor activity. Biological Process: cell proliferation; positive regulation of neurogenesis; negative regulation of angiogenesis; ovulation cycle; short-term memory; retina development in camera-type eye; multicellular organismal development; negative regulation of inflammatory response; response to arsenic; response to acidity; kidney development; aging. Disease: Osteogenesis Imperfecta, Type Vi

size1 :

0.05 mL

price1 :

240 USD

size2 :

0.1 mL

price2 :

315