catalog number :
MBS200020
products full name :
AK3 antibody (clone SJB3-36)
products short name :
AK3
products name syn :
adenylate kinase; Ak6; FIX; Ak3L1; AkL3L; AkL3L1; adenylate kinase 3; adenylate kinase 6; adenylate kinase 3 like 1
other names :
GTP:AMP phosphotransferase AK3, mitochondrial isoform a; GTP:AMP phosphotransferase AK3, mitochondrial; GTP:AMP phosphotransferase AK3, mitochondrial; GTP:AMP phosphotransferase, mitochondrial; adenylate kinase 3 alpha-like 1; adenylate kinase 6, adenylate kinase 3 like 1; adenylate kinase 3; Adenylate kinase 3; Adenylate kinase 3 alpha-like 1
other gene names :
AK3; AK3; AK6; FIX; AK3L1; AKL3L; AKL3L1
uniprot entry name :
KAD3_HUMAN
reactivity :
Human, Mouse
purity :
By protein-G affinity chromatography
form :
Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.
storage stability :
Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.
tested application :
ELISA (EIA), Western Blot (WB) (Recombinant protein,Cell lysate), Immunohistochemistry (IHC)
app notes :
The antibody has been tested by ELISA, Western blot and immunohistochemistry analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1:2,000. Recommended starting dilution is 1:1,000.
other info1 :
Antigen Species: Human. Clone: Anti-human Ak3 mAb, clone SJB3-36, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Ak3 protein. Immunogen: Recombinant human Ak3 (adenylaste kinase isozyme 3) purified from E Coli
products categories :
Signal Transduction
products description :
Adenylate kinase (Ak; adenosine triphosphate-adenosine monophosphate [ATP-AMP] phospho-transferase, EC 2.7.4.3) is a ubiquitous monomeric enzyme involved energy metabolism of prokaryotic and eukaryotic cells. Three isozymes (Ak1, Ak2 and Ak3) are characterized in vertebrates. Ak1 is present in the cytosol of skeletal muscle, brain, and erythrocyte, while Ak2 is localized in the intermembrane space of mitochondria of liver, kidney, spleen and heart. Ak3, called GTP:AMP phosphotransferase, exists in the mitochondrial matrix of liver and heart. These isozymes contribute to homeostasis of the adenine nucleotide composition in the cell.
products references :
Noda, L.H. et al. (1973) The Enzymes. Vol. 8, 279-305 khoo, J.C. et al. (1972) Biochim. Biophys. Acta 268, 98-101 Tomasselli, A.G. et al. (1979) Eur.J.Biochemolecules 93, 257-262 Lee, Y. et al. (1998) J. Biochem. 123, 47-54.
ncbi gb acc num :
NM_016282.3
ncbi mol weight :
21,014 Da
ncbi pathways :
Adenine Ribonucleotide Biosynthesis, IMP = ADP,ATP Pathway 618580!!Adenine Ribonucleotide Biosynthesis, IMP = ADP,ATP Pathway 468242!!Factors Involved In Megakaryocyte Development And Platelet Production Pathway 187196!!Hemostasis Pathway 106028!!Purine Metabolism Pathway 82944!!Purine Metabolism Pathway 307
ncbi summary :
The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]