KIR2DS4 antibody (clone 5F2) | MyBioSource MBS200014 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

KIR2DS4 antibody (clone 5F2)

catalog :

MBS200014

quantity :

0.05 ml

price :

240 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5F2

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

product information

catalog number :

MBS200014

products type :

Antibody

products full name :

KIR2DS4 antibody (clone 5F2)

products short name :

KIR2DS4

products name syn :

KIR2DS4; CD158I; KKA3; NKAT8; KIR2DS4; p50 KIR; CD158; MHC class I NK cell receptor; Natural killer-associated transcript 8; NKAT-8; P58 natural killer cell receptor clone CL-39; p58 NK receptor; CL-17; CD158 antigen-like family member I; CD15; Killer cell immunoglobulin-like receptor 2DS4; Killer cell immunoglobulin-like receptor 2DS4; CD158 antigen like family member I; CD158i antigen; CL 17; CL 39; CL17; CL39; Killer cell immunoglobulin like receptor two domains short cytoplasmic tail 4; Killer inhibitory receptor 4 1 2; KIR antigen 2DS4; KIR1D; KIR412; MGC120019; MGC125315; MGC125317; MHC class I NK cell receptor; Natural killer associated transcript 8; Natural killer cell inhibitory receptor; NKAT 8; P58 natural killer cell receptor clone CL 39; p58 NK receptor

other names :

killer cell immunoglobulin-like receptor 2DS4 isoform 1; Killer cell immunoglobulin-like receptor 2DS4; killer cell immunoglobulin-like receptor 2DS4; CD158 antigen-like family member I; KIR antigen 2DS4; MHC class I NK cell receptor; P58 natural killer cell receptor clones CL-39/CL-17; killer Ig receptor; killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 1; killer inhibitory receptor 4-1-2; natural killer cell inhibitory receptor; natural killer-associated transcript 8; p58 NK receptor CL-39/CL-17; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4; CD158 antigen-like family member I; MHC class I NK cell receptor; Natural killer-associated transcript 8; NKAT-8; P58 natural killer cell receptor clones CL-39/CL-17; p58 NK receptor CL-39/CL-17; CD_antigen: CD158i

products gene name :

KIR2DS4

other gene names :

KIR2DS4; KIR2DS4; KKA3; KIR1D; NKAT8; CD158I; KIR412; NKAT-8; KIR2DS1; CD158I; KKA3; NKAT8; NKAT-8; p58 NK receptor CL-39/CL-17

uniprot entry name :

KI2S4_HUMAN

clonality :

Monoclonal

isotype :

IgG2b, k

clone :

5F2

host :

Mouse

reactivity :

Human

sequence length :

304

purity :

By protein-G affinity chromatography

form :

Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

concentration :

1mg/ml

storage stability :

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

tested application :

ELISA (EIA), Western Blot (WB) (Recombinant protein)

app notes :

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 2,000. Recommended starting dilution is 1:1,000.

other info1 :

Antigen Species: Human. Clone: Anti-human kIR2DS4 mAb, clone 5F2, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human kIR2DS4 protein. Immunogen: Recombinant human kIR2DS4 purified from E Coli

products categories :

Immunology

products description :

The KIR family consists of transmembrane glycoproteins of the Ig superfamily expressed on human Nk cells and a subset of human T cells which they are involved in recognition of either MHC class I molecules or unknown ligand on target cells and inhibit cytotoxic activities. KIR2DS4 is an activating receptor of KIR family.

products references :

Steffens, U. et al. (1998) Tissue Antigens 51:398-413 kim, J. et al. (1997) J. Immunol. 159:3875-3882 Wagtmann, N. R., et al. (1995) Immunity 2:439-449

ncbi gi num :

116517309

ncbi acc num :

NP_036446

ncbi gb acc num :

NM_012314.5

ncbi mol weight :

33,583 Da

ncbi pathways :

Antigen Processing And Presentation Pathway 83074!!Antigen Processing And Presentation Pathway 485!!DAP12 Interactions Pathway 685549!!Immune System Pathway 106386!!Innate Immune System Pathway 106387!!Natural Killer Cell Mediated Cytotoxicity Pathway 83079!!Natural Killer Cell Mediated Cytotoxicity Pathway 490

ncbi summary :

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

size :

0.05 ml

price :

240 USD