antibody

KIR2DL3 antibody (clone190IIC311)

MBS200001

0.05 ml

240 USD

monoclonal

mouse

nonconjugated

190IIC311

western blot, ELISA, flow cytometry, FACS, enzyme immunoassay

Antibody

KIR2DL3 antibody (clone190IIC311)

KIR2DL3

KIR2DL3; CD158B2; KIRCL23; NKAT2; KIR2DL3 (p58 KIR; CD158); MHC class I NK cell receptor; Natural killer-associated transcript 2; NKAT-2; NKAT2a; NKAT2b; p58 natural killer cell receptor clone CL-6; p58 NK receptor; p58.2 MHC class-I-specific NK re; Killer cell immunoglobulin-like receptor 2DL3; Killer cell immunoglobulin-like receptor 2DL3 CD158b; GL183; Killer Cell Immunoglobulin Like Receptor 2DL3; Killer inhibitory receptor CL2 3; KIR023GB; MHC Class I NK Cell Receptor; Natural Killer Associated Transcript 2; p58; p58 Natural Killer Cell Receptor Clone CL6; p58.2 MHC Class I Specific NK Receptor

Killer cell immunoglobulin-like receptor 2DL3; killer cell immunoglobulin-like receptor 2DL3; CD158 antigen-like family member B2; MHC class I NK cell receptor; NK-receptor; NKAT-2; killer Ig-like inhibitory receptor; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5; killer inhibitory receptor cl 2-3; natural killer associated transcript 2; natural killer cell inhibitory receptor KIR2DL3; natural killer-associated transcript 2; p58 NK receptor CL-6; p58 natural killer cell receptor clone CL-6; p58.2 MHC class-I specific NK receptor; p58.2 MHC class-I-specific NK receptor; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3; CD158 antigen-like family member B2; KIR-023GB; Killer inhibitory receptor cl 2-3; MHC class I NK cell receptor; NKAT2a; NKAT2b; Natural killer-associated transcript 2; NKAT-2; p58 natural killer cell receptor clone CL-6; p58 NK receptor CL-6; p58.2 MHC class-I-specific NK receptor; CD_antigen: CD158b2

KIR2DL3

KIR2DL3; KIR2DL3; p58; NKAT; GL183; NKAT2; CD158b; NKAT2A; NKAT2B; CD158B2; KIR-K7b; KIR-K7c; KIR2DS5; KIRCL23; KIR-023GB; CD158B2; KIRCL23; NKAT2; NKAT-2; p58 NK receptor CL-6

KI2L3_HUMAN

Monoclonal

IgG2a, k

190IIC311

Mouse

Human

243

By protein-G affinity chromatography

Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

1mg/ml

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

ELISA (EIA), Western Blot (WB) (Recombinant protein), Flow Cytometry (FC/FACS)

The antibody has been tested by ELISA, Western blot and immunofluorescent staining with flow cytometric analysis to assure specificity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Applications include flow cytometry (5-10g/1x106), ELISA (1:1,000 when tested against the immunized protein) and western blot analysis (1ug/ml). Note: this product is routinely tested on peripheral blood mononuclear cells(PBMCs) or natural Killer(NK) cells. The histogram is an example of the expected reactivity.

Antigen Species: Human. Clone: Anti-human KIR2DL3 mAb, clone 190IIC311, is derived from hybridization of mouse P3-x63-Ag8.653 myeloma cells with spleen cells from BALB/c mice immunized with recombinant KIR2DL3. Immunogen: Recombinant human KIR2DL3 (19-161aa) purified from E Coli

Immunology

Reacts with extracellular domain of the KIR2DL3, a member of the Killer cell immunoglobulin-liKe receptor(KIR) family. The KIR family consists of transmembrane glycoproteins of the Ig superfamily expressed on human NK cells and a subset of human T cells which they are involved in recognition of either MHC class I molecules or unKnown ligand on target cells and inhibit cytotoxic activities.

Shin JS, et al., (1999) Hybridoma 18:521-527. Chwae YJ, et al., (2002) J Immunology 169:3726-3735.

71143143

NP_055326

NM_014511.3

27,269 Da

Adaptive Immune System Pathway 366160!!Antigen Processing And Presentation Pathway 83074!!Antigen Processing And Presentation Pathway 485!!DAP12 Interactions Pathway 685549!!Graft-versus-host Disease Pathway 83124!!Graft-versus-host Disease Pathway 536!!Immune System Pathway 106386!!Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway 106413!!Innate Immune System Pathway 106387!!Natural Killer Cell Mediated Cytotoxicity Pathway 83079

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

0.05 ml

240 USD