Recombinant Human Cardiac Troponin T (TnT) | MyBioSource MBS197054 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Cardiac Troponin T (TnT)

catalog :

MBS197054

quantity :

0.005 mg

price :

195 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS197054

products type :

Recombinant Protein

products full name :

Recombinant Human Cardiac Troponin T (TnT)

products short name :

Cardiac Troponin T (TnT)

other names :

troponin T, cardiac muscle isoform 1; Troponin T, cardiac muscle; troponin T, cardiac muscle; OTTHUMP00000033864; OTTHUMP00000033865; OTTHUMP00000033866; OTTHUMP00000033867; OTTHUMP00000033870; OTTHUMP00000218095; troponin T2, cardiac; cardiac muscle troponin T; cardiomyopathy, hypertrophic 2; cardiomyopathy, dilated 1D (autosomal dominant); troponin T type 2 (cardiac); Cardiac muscle troponin T

other gene names :

TNNT2; TNNT2; CMH2; RCM3; TnTC; cTnT; CMPD2; LVNC6; MGC3889

uniprot entry name :

TNNT2_HUMAN

host :

E Coli

sequence :

MGSSHHHHHH SSGLVPRGSH MSDIEEVVEE YEEEEQEEAA VEEQEEAAEE DAEAEAETEE TRAEEDEEEE EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED EARKKKALSN MMHFGGYIQK TERKSGKRQT EREKKKKILA ERRKVLAIDH LNEDQLREKA KELWQSIYNL EAEKFDLQEK FKQQKYEINV LRNRINDNQK VSKTRGKAKV TGRWK

specificity :

Human Cardiac Troponin T (TnT)

purity :

Greater than 90% as determined by SDS-PAGE

form :

Sterile-filtered solution in 20mM Tris, pH 8.0, 10% glycerol. Purified by proprietary chromatographic techniques.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store at -20 degree C for longer periods of time. For long term storage, additon of 0.1% human serum albumin or bovine serum albumin is recommended. Avoid multiple freeze-thaw cycles.

other info1 :

Accession Number: P45379.3

products description :

Troponin T (TnT) is the tropomyosinbinding subunit of the troponin complex which is situated on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentrations. Mutations in the TNNT2 gene are associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy and hypertrophic cardiomyopathy. Recombinant Human TnT produced in E. coli is a single, non-glycosylated polypeptide chain containing 305 amino acids (aa 1-285) with a molecular weight of 36.4 kDa. It is fused to a 20-amino acid His-tag at the N-terminus.

ncbi gi num :

48255877

ncbi acc num :

NP_000355.2

ncbi gb acc num :

NM_000364.2

uniprot acc num :

P45379

ncbi mol weight :

35,924 Da

ncbi pathways :

Cardiac Muscle Contraction Pathway (93344); Cardiac Muscle Contraction Pathway (93992); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114229); Hypertrophic Cardiomyopathy (HCM) Pathway (106591); Muscle Contraction Pathway (106261); Striated Muscle Contraction Pathway (106262); Striated Muscle Contraction Pathway (198903)

ncbi summary :

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq]

uniprot summary :

TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing. Protein type: Motor; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament. Molecular Function: troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; actin binding; tropomyosin binding. Biological Process: atrial cardiac muscle morphogenesis; positive regulation of ATPase activity; metabolic process; regulation of muscle contraction; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding. Disease: Cardiomyopathy, Familial Restrictive, 3; Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2

size1 :

0.005 mg

price1 :

195 USD

size2 :

0.02 mg

price2 :

280

size3 :

1 mg

price3 :

4110

more info or order :

MyBioSource product webpage