protein

Recombinant Human Cu/Zn Superoxide Dismutase Monomer

MBS197036

0.005 mg

195 USD

Recombinant Protein

Recombinant Human Cu/Zn Superoxide Dismutase Monomer

Cu/Zn Superoxide Dismutase Monomer

superoxide dismutase; Superoxide dismutase [Cu-Zn]; superoxide dismutase [Cu-Zn]; superoxide dismutase [Cu-Zn]; SOD, soluble; OTTHUMP00000107278; OTTHUMP00000107279; indophenoloxidase A; Cu/Zn superoxide dismutase; superoxide dismutase, cystolic; superoxide dismutase 1, soluble; Superoxide dismutase 1

SOD1; SOD1; ALS; SOD; ALS1; IPOA; hSod1; homodimer

SODC_HUMAN

E Coli

MATKAVCVLK GDGPVQGIIN FEQKESNGPV KVWGSIKGLT EGLHGFHVHE FGDNTAGCTS AGPHFNPLSR KHGGPKDEER HVGDLGNVTA DKDGVADVSI EDSVISLSGD HCIIGRTLVV HEKADDLGKG GNEESTKTGN AGSRLACGVIGIAQ

Human Cu/Zn Superoxide Dismutase Monomer

Greater than 95% as determined by SDS- PAGE and RPHPLC.

Sterile-filtered solution in 20mM Tris, pH 7.5 and 20% glycerol. Purified by proprietary chromatographic techniques.

Although stable at 4 degree C for 4 weeks, product is best stored at or below -20 degree C. Addition of a carrier protein (such as 0.1% HSA or BSA) is recommended for long-term storage.

Cu/Zn Superoxide Dismutase (SOD1) catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. It protects a cell from dangerous levels of superoxide. SOD1 binds copper and zinc ions and is one of three isozymes responsible for destroying free superoxide radicals. Mutations in SOD1 cause a form of familial amyotrophic lateral sclerosis (ALS). Recombinant Human Cu/Zn SOD1 produced in E. coli is a single monomeric non-glycosylated polypeptide chain containing 154 amino acids with a molecular weight of 15.9kDa.

4507149

NP_000445.1

NM_000454.4

P00441

15,936 Da

Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); FOXA1 Transcription Factor Network Pathway (137979); Folate Metabolism Pathway (198833); Formation Of Platelet Plug Pathway (106029); Hemostasis Pathway (106028); Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Oxidative Stress Pathway (198916); Peroxisome Pathway (131226)

The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq]

SOD1: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Homodimer; non-disulfide linked. Homodimerization may take place via the ditryptophan cross-link at Trp-33. The pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not. The pathogenic variants ALS1 Arg-86 and Ala-94 interact with MARCH5, whereas wild-type protein does not. Belongs to the Cu-Zn superoxide dismutase family. Protein type: Apoptosis; Nuclear receptor co-regulator; Mitochondrial; EC 1.15.1.1; Oxidoreductase. Chromosomal Location of Human Ortholog: 21q22.11. Cellular Component: dendrite cytoplasm; extracellular space; protein complex; mitochondrion; extracellular region; mitochondrial intermembrane space; cytosol; nucleoplasm; extracellular matrix; cell soma; mitochondrial matrix; cytoplasm; plasma membrane; peroxisome; cytoplasmic vesicle; nucleus. Molecular Function: identical protein binding; protein binding; protein homodimerization activity; copper ion binding; zinc ion binding; chaperone binding; superoxide dismutase activity; Rac GTPase binding; protein phosphatase 2B binding. Biological Process: positive regulation of catalytic activity; activation of MAPK activity; cellular iron ion homeostasis; positive regulation of apoptosis; myeloid cell homeostasis; retrograde axon cargo transport; muscle maintenance; response to antibiotic; retinal homeostasis; glutathione metabolic process; regulation of mitochondrial membrane potential; neurofilament cytoskeleton organization and biogenesis; positive regulation of superoxide release; negative regulation of neuron apoptosis; placenta development; positive regulation of cytokine production; response to drug; platelet activation; cell aging; transmission of nerve impulse; regulation of organ growth; response to reactive oxygen species; response to ethanol; heart contraction; response to heat; superoxide release; relaxation of vascular smooth muscle; removal of superoxide radicals; locomotory behavior; response to organic substance; platelet degranulation; sensory perception of sound; ovarian follicle development; regulation of blood pressure; auditory receptor cell stereocilium organization and biogenesis; response to axon injury; negative regulation of cholesterol biosynthetic process; anterograde axon cargo transport; response to nutrient levels; response to superoxide; thymus development; regulation of T cell differentiation in the thymus; response to amphetamine; superoxide metabolic process; myelin maintenance in the peripheral nervous system; regulation of multicellular organism growth; response to copper ion; response to hydrogen peroxide; spermatogenesis; blood coagulation; regulation of protein kinase activity; embryo implantation; hydrogen peroxide biosynthetic process. Disease: Amyotrophic Lateral Sclerosis 1

0.005 mg

195 USD

0.025 mg

280

1 mg

3295