Recombinant Human Parathyroid Hormone(rHuPTH) | MyBioSource MBS197018 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Parathyroid Hormone(rHuPTH)

catalog :

MBS197018

quantity :

0.1 mg

price :

330 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS197018

products type :

Recombinant Protein

products full name :

Recombinant Human Parathyroid Hormone(rHuPTH)

products short name :

Parathyroid Hormone (rHuPTH)

products name syn :

Recombinant Human Parathyroid Hormone (rHuPTH)

other names :

Parathyroid hormone; Parathyroid hormone; parathyroid hormone; parathyrin; parathormone; OTTHUMP00000230966; parathyroid hormone 1; parathyroid hormone; Parathormone; Parathyrin

other gene names :

PTH; PTH; PTH1

uniprot entry name :

PTHY_HUMAN

host :

E Coli

sequence length :

115

specificity :

Recombinant Human Parathyroid Hormone (rHuPTH)

purity :

Greater than 98% by RP-HPLC, anion-exchange chromatography; reducing and non-reducing SDS-PAGE, silver stain. Purification: Chromatographic

form :

Sterile filtered, lyophilized.

storage stability :

Lyophilized product is stable at room temperature for 3 weeks. Store lyophilized product desiccated at -20 degree C. Upon reconstitution, store at 4 degree C for 2-7 days or aliquot and store at -20 degree C. For long-term storage add either HSA or BSA to 0.1%. Avoid repeated freeze-thaw cycles.

other info1 :

Dimers/Aggregates: <1% by SDSPAGE. Biological Activity: Fully biologically active compared to reference standards. Specific Activity 1 x 10^4 Units/mg.

other info2 :

Endotoxin Level: <0.1 ng/ug. Protein Content: Determined spectrophotometrically at 280nm and by RP-HPLC analysis against a calibrated standard. Solubility: Reconstitute the lyophilized product in sterile water not less than 100 ug/ml. Stabilizer: None. Preservatives: None

products categories :

Recombinant Proteins

products description :

Recombinant Human PTH produced in E. coli is a single, non-glycosylated, polypeptide chain containing 34 amino acids with a molecular mass of 4,118 daltons. This product has full biological activity.

ncbi gi num :

64654689

ncbi acc num :

AAH96144.1

uniprot acc num :

P01270

ncbi mol weight :

12,861 Da

ncbi pathways :

Class B/2 (Secretin Family Receptors) Pathway (106378); Endochondral Ossification Pathway (198812); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Osteoblast Signaling Pathway (198842); Signaling By GPCR Pathway (106356)

ncbi summary :

The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH). [provided by RefSeq]

uniprot summary :

PTH: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism. Belongs to the parathyroid hormone family. Protein type: Secreted; Hormone; Secreted, signal peptide; Apoptosis. Chromosomal Location of Human Ortholog: 11p15.3-p15.1. Cellular Component: extracellular space; extracellular region. Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; type 1 parathyroid hormone receptor binding; parathyroid hormone receptor binding; peptide hormone receptor binding; hormone activity. Biological Process: response to drug; transcription from RNA polymerase II promoter; positive regulation of signal transduction; induction of apoptosis by hormones; positive regulation of glycogen biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of bone mineralization; G-protein signaling, adenylate cyclase activating pathway; Rho protein signal transduction; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; positive regulation of glucose import; cAMP metabolic process; response to ethanol; response to cadmium ion; response to vitamin D; cell-cell signaling; regulation of gene expression; positive regulation of cAMP biosynthetic process; response to lead ion; positive regulation of transcription from RNA polymerase II promoter; skeletal development; bone resorption. Disease: Hypoparathyroidism, Familial Isolated

size1 :

0.1 mg

price1 :

330 USD

size2 :

0.5 mg

price2 :

600

size3 :

1 mg

price3 :

885

more info or order :

MyBioSource product webpage