Recombinant Human Keratinocyte Growth Factor | MyBioSource MBS197014 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Keratinocyte Growth Factor

catalog :

MBS197014

quantity :

0.002 mg

price :

195 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS197014

products type :

Recombinant Protein

products full name :

Recombinant Human Keratinocyte Growth Factor

products short name :

Keratinocyte Growth Factor (rHuKGF)

products name syn :

Recombinant Human Keratinocyte Growth Factor (rHuKGF)

other names :

keratinocyte growth factor; Keratinocyte growth factor; keratinocyte growth factor; FGF-7; OTTHUMP00000162252; heparin-binding growth factor 7; fibroblast growth factor 7; Fibroblast growth factor 7; FGF-7; Heparin-binding growth factor 7

other gene names :

FGF7; FGF7; KGF; HBGF-7; KGF

uniprot entry name :

FGF7_HUMAN

host :

E Coli

specificity :

Recombinant Human Keratinocyte Growth Factor (rHuKGF)

purity :

Greater than 97% by RP-HPLC, anion-exchange chromatography; reducing and non-reducing SDS-PAGE, silver stain. Purification: Chromatographic

form :

Sterile filtered, lyophilized.

storage stability :

Lyophilized product is stable at room temperature for 3 weeks. Store lyophilized product desiccated at -20 degree C. Upon reconstitution, store at 4 degree C for 2-7 days or aliquot and store at -20 degree C. For long-term storage add either HSA or BSA to 0.1%. Avoid repeated freeze-thaw cycles.

other info1 :

Dimers/Aggregates: <1% by SDSPAGE. Biological Activity: Fully biologically active compared to reference standards. Specific Activity is 105 Units/mg.

other info2 :

Endotoxin Level: <0.1 ng/ug. Protein Content: Determined spectrophotometrically at 280nm (extinction coefficient 0.9) and by RPHPLC analysis against a calibrated standard. Solubility: Reconstitute the lyophilized product in sterile water not less than 100 ug/ml. Stabilizer: None. Preservatives: None

products categories :

Recombinant Proteins

products description :

Recombinant Human KGF produced in E. coli is a single, non-glycosylated, polypeptide chain containing 164 amino acids with a molecular mass of 18,995 daltons. This product has full biological activity.

ncbi gi num :

4503705

ncbi acc num :

NP_002000.1

ncbi gb acc num :

NM_002009.3

uniprot acc num :

P21781

ncbi mol weight :

22,509 Da

ncbi pathways :

Downstream Signaling Of Activated FGFR Pathway (160957); FGFR Ligand Binding And Activation Pathway (106344); FGFR2 Ligand Binding And Activation Pathway (106349); FGFR2b Ligand Binding And Activation Pathway (106350); FRS2-mediated Cascade Pathway (160958); Glypican 3 Network Pathway (138084); IRS-mediated Signalling Pathway (106426); IRS-related Events Pathway (106424); Insulin Receptor Signalling Cascade Pathway (106420); MAPK Signaling Pathway (83048)

ncbi summary :

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq]

uniprot summary :

FGF7: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. Belongs to the heparin-binding growth factors family. Protein type: Cytokine; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 15q21.2. Cellular Component: Golgi apparatus; extracellular region. Molecular Function: heparin binding; protein binding; growth factor activity; chemoattractant activity; fibroblast growth factor receptor binding. Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of keratinocyte migration; epidermis development; hair follicle morphogenesis; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; mesenchymal cell proliferation; signal transduction; positive regulation of peptidyl-tyrosine phosphorylation; positive chemotaxis; positive regulation of cell division; positive regulation of cell proliferation; actin cytoskeleton reorganization; response to wounding; insulin receptor signaling pathway; innate immune response; positive regulation of epithelial cell proliferation

size1 :

0.002 mg

price1 :

195 USD

size2 :

0.01 mg

price2 :

280

size3 :

1 mg

price3 :

5650

more info or order :

MyBioSource product webpage