Recombinant Human Insulin-Like Growth Factor II(rHuIGF-II) | MyBioSource MBS197012 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Insulin-Like Growth Factor II(rHuIGF-II)

catalog :

MBS197012

quantity :

0.01 mg

price :

205 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS197012

products type :

Recombinant Protein

products full name :

Recombinant Human Insulin-Like Growth Factor II(rHuIGF-II)

products short name :

Insulin-Like Growth Factor II (rHuIGF-II)

products name syn :

Recombinant Human Insulin-Like Growth Factor II (rHuIGF-II)

other names :

insulin-like growth factor II isoform 2; Insulin-like growth factor II; insulin-like growth factor II; somatomedin-A; OTTHUMP00000011012; OTTHUMP00000011013; OTTHUMP00000011015; OTTHUMP00000011018; OTTHUMP00000011157; OTTHUMP00000011158; OTTHUMP00000220677; insulin-like growth factor type 2; insulin-like growth factor 2 (somatomedin A); Somatomedin-A

other gene names :

IGF2; IGF2; IGF-II; PP9974; C11orf43; FLJ22066; FLJ44734

uniprot entry name :

IGF2_HUMAN

host :

E Coli

sequence length :

180

specificity :

Recombinant Human Insulin-Like Growth Factor II (rHuIGF-II)

purity :

Greater than 97% by RP-HPLC, anion-exchange chromatography; reducing and non-reducing SDS-PAGE, silver stain. Purification: Chromatographic

form :

Sterile filtered, lyophilized.

storage stability :

Lyophilized product is stable at room temperature for 3 weeks. Store lyophilized product desiccated at -20 degree C. Upon reconstitution, store at 4 degree C for 2-7 days or aliquot and store at -20 degree C. For long-term storage add either HSA or BSA to 0.1%. Avoid repeated freeze-thaw cycles.

other info1 :

Dimers/Aggregates: <1% by SDSPAGE. Biological Activity: Fully biologically active compared to reference standards. Specific activity is 1 x 10^6 IU/mg.

other info2 :

Endotoxin Level: <0.1 ng/ug. Protein Content: Determined spectrophotometrically at 280nm and by RP-HPLC analysis against a calibrated standard. Solubility: Reconstitute the lyophilized product in sterile water not less than 100 ug/ml. Stabilizer: None. Preservatives: None

products categories :

Recombinant Proteins

products description :

Recombinant Human IGF-II produced in E. coli is a single, non-glycosylated polypeptide chain containing 67 amino acids with a molecular mass of 7,505 daltons. This product has full biological activity.

ncbi gi num :

189083846

ncbi acc num :

NP_001121070.1

ncbi gb acc num :

NM_001127598.1

uniprot acc num :

P01344

ncbi mol weight :

20,140 Da

ncbi pathways :

Apoptosis Pathway 198797!!Diabetes Pathways 105902!!Endochondral Ossification Pathway 198812!!Hedgehog Signaling Pathway 198835!!Regulation Of Insulin-like Growth Factor (IGF) Activity By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway 105908

ncbi summary :

This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

uniprot summary :

Function: The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development. Ref.27Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. Ref.27. Subcellular location: Secreted. Post-translational modification: O-glycosylated with a core 1 or possibly core 8 glycan. Ref.26 Ref.29. Polymorphism: Genetic variations in IGF2 are associated with body mass index (BMI). The BMI is a statistical measurement which compares a person's weight and height. Involvement in disease: Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SIRS) [. MIM:180860]. SIRS is a clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. Sequence similarities: Belongs to the insulin family. Mass spectrometry: Molecular mass is 7469.4 Da from positions 25 - 91. Determined by MALDI. Ref.24 Ref.25Molecular mass is 7398.3 Da from positions 26 - 91. Determined by MALDI. Ref.24 Ref.25

size :

0.01 mg

price :

205 USD

more info or order :

MyBioSource product webpage