Recombinant Human Granulocyte Macrophage Colony Stimulating Factor (rHuGM-CSF) | MyBioSource MBS197007 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Granulocyte Macrophage Colony Stimulating Factor (rHuGM-CSF)

catalog :

MBS197007

quantity :

0.005 mg

price :

195 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS197007

products type :

Recombinant Protein

products full name :

Recombinant Human Granulocyte Macrophage Colony Stimulating Factor (rHuGM-CSF)

products short name :

Granulocyte Macrophage Colony Stimulating Factor (rHuGM-CSF)

products name syn :

Recombinant Human Granulocyte Macrophage Colony Stimulating Factor (rHuGM-CSF)

other names :

granulocyte-macrophage colony-stimulating factor; Granulocyte-macrophage colony-stimulating factor; granulocyte-macrophage colony-stimulating factor; CSF; molgramostin; sargramostim; OTTHUMP00000065962; granulocyte-macrophage colony stimulating factor; colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; Molgramostin; Sargramostim

other gene names :

CSF2; CSF2; GMCSF; MGC131935; MGC138897; GMCSF

uniprot entry name :

CSF2_HUMAN

host :

E Coli

sequence :

AMINO ACID SEQUENCE. The first five N-terminal amino acids are Ala-Pro-Ala-Arg-Ser. N-terminal methionine is removed enzymatically.

specificity :

Recombinant Human Granulocyte Macrophage Colony Stimulating Factor (rHuGM-CSF)

purity :

>98% as determined by RPHPLC and SDS-PAGE.

form :

Sterile filtered and lyophilized after dialysis against 2mM sodium phosphate, pH 7.4. Purified by proprietary chromatographic techniques.

storage stability :

Reconstitute lyophilized GM-CSF in sterile distilled H20 at not less than 100ug/ml. This can be further diluted in other aqueous solutions. Store lyophilized product desiccated below -18 degree C. After reconstitution, GMCSF may be stored at 4 degree C for 2-7 days and below -18 degree C for future use. For long term storage, addition of 0.1 % human serum albumin or bovine serum albumin is recommended. Avoid multiple freeze-thaw cycles.

other info2 :

Biological Activity: E050 by dose-dependent stimulation of proliferation of human TF-1 cells (human erythroleukemic indicator cell line) is <0.1ng/ml which corresponds to a Specific Activity of 11,100,000 IU/mg.

products categories :

Recombinant Proteins

products description :

Describtion: Recombinant human GM-CSF produced in E. coli is a single, non-glycosylated polypeptide containing 127 amino acids with a molecular weight of 14,4770a. Background: GM-CSF was first identified as a growth factor that supports in vitro colony formation of granulocyte-macrophage progenitor cells. It is produced in response to immune or inflammatory stimuli by activated T cells, B cells, macrophages, mast cells, fibroblasts, and alveolar epithelial cells. GM-CSF is a 22kOa protein, 144 amino acids, composed of four bundle alpha helices.

ncbi gi num :

27437030

ncbi acc num :

NP_000749.2

ncbi gb acc num :

NM_000758.2

uniprot acc num :

P04141 .1

ncbi mol weight :

16,295 Da

ncbi pathways :

Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Cytokines And Inflammatory Response Pathway (198794); Fc Epsilon RI Signaling Pathway (83082); Fc Epsilon RI Signaling Pathway (493)

ncbi summary :

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq]

uniprot summary :

GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family. Protein type: Cytokine; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 5q31.1. Cellular Component: extracellular space; extracellular region. Molecular Function: protein binding; growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity. Biological Process: negative regulation of cytolysis; epithelial fluid transport; macrophage activation; embryonic placenta development; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of interleukin-23 production; positive regulation of cell proliferation; immune response; myeloid dendritic cell differentiation; positive regulation of DNA replication

size1 :

0.005 mg

price1 :

195 USD

size2 :

0.02 mg

price2 :

280

size3 :

1 mg

price3 :

3435

more info or order :

MyBioSource product webpage