catalog number :
MBS194478
products full name :
NMDAR NR3A/B Antibody
products short name :
Glutamate NMDA Receptor NR3A/B Subunit
products name syn :
Anti-Glutamate NMDA Receptor NR3A/B Subunit; Glutamate NMDA Receptor NR3A/B Subunit
specificity :
Anti-Glutamate NMDA Receptor NR3A/B Subunit [Mouse antibody generated to a fusion peptide of NR3A corresponding to C-terminus aa 780-914. Also detects subunit NR3B. Useful in Western Blot and Immunohistochemistry.]. This antibody recognizes NMDAR subunits NR3A and NR3B. It does not cross-react with subunits NR1 or NR2A-D.
form :
100 ug IgG1 in 100 ul PBS, pH 7.4,purified by Protein G Chromatography
storage stability :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
tested application :
Western Blot, Immunoblot, Immunoprecipitation
app notes :
Immunoblotting: Use at 1-10 ug/ml. Western Blot: Use at 1-10 ug/ml Immunoprecipitation
other info1 :
Immunogen: Fusion protein of NR3A aa sequence 780-914 from the extracellular III-IV loop.
other info2 :
Stabilizer: None. Preservatives: None. Dilutions Instructions: Dilute in PBS or medium that is appropriate for the assay system.
products categories :
Neuroscience and Signal Transduction Antibodies
products description :
Two new subunits of the NMDA subtype of glutamate receptor (NMDAR) have been identified, NR3A and NR3B, with NR3B likely being the final member of the NMDAR family. These subunits show high sequence homology, although different distribution patterns: NR3B is expressed predominately in motor neurons, while NR3A is more widely distributed. When expressed in Xenopus oocytes, NR3A or NR3B assemble with NR1 to form excitatory glycine receptors that are unaffected by glutatmate.
products references :
Chatterton, et. al. Nature 415: 793-79 (2002). Wong, et. al., J. Comp. Neurol. 450: 303- 317 (2002). Perez-Otano, et. al., J. Neurosci. 21: 1228- 1237 (2001). Sasaki, et. al., J. Neurophysiol. 87: 2052-2063 (2002)