Toll-like Receptor 3 (TLR3) Polyclonal Antibody | MyBioSource MBS194448 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Toll-like Receptor 3 (TLR3) Polyclonal Antibody

catalog :

MBS194448

quantity :

0.05 mg

price :

505 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS194448

products type :

Antibody

products full name :

Toll-like Receptor 3 (TLR3) Polyclonal Antibody

products short name :

Toll-like Receptor 3 (TLR3)

products name syn :

Toll-like Receptor 3 (TLR3)

other names :

toll-like receptor 3; Toll-like receptor 3; toll-like receptor 3; toll-like receptor 3

other gene names :

Tlr3; Tlr3; Tlr3

uniprot entry name :

Q7TNI8_RAT

clonality :

Polyclonal

host :

Rabbit

sequence length :

905

specificity :

Toll-like Receptor 3 (TLR3) [Rabbit polyclonal antibody recognizes human and mouse TLR3]. This antibody recognizes human and mouse TLR3.

form :

50 ug purified by antigen affinity chromatography in PBS containing 0.02% sodium azide.

storage stability :

Store at 4 degree C. Avoid freezing.

tested application :

Western Blot, Immunohistochemistry

app notes :

Western Blotting: use at 1-2ug/ml. A band of approximately 97 kDa is detected. Immunohistochemistry: formalin-fixed, paraffin-embedded tissues, use at 5ug/ml.

other info1 :

Antigen: Synthetic peptide corresponding to 15 amino acids near the N-terminus of human TLR3.

other info2 :

Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

products categories :

Neuroscience and Signal Transduction Antibodies

products description :

TLR3 is a 904 aa protein with 24 N-terminal leucine-rich repeat motifs (LRRs) and a molecular weight of 97 kDa. TLR3 is most closely related to TLR5, TLR7, and TLR8, each with 26% overall sequence identity. In vivo, two different sized transcripts for TLR3 are observed suggesting that the mRNA is alternatively spliced to generate two different forms of the protein. TLR3 mRNA is expressed at highest levels in placenta and pancreas. There are conflicting reports regarding the expression of TLR3 in particular leukocyte populations. Some suggest that TLR3 is only expressed by dendritic cells (DCs), while others find that TLR3 is expressed by T or NK cells. While it is generally assumed that TLRs are expressed on the cell surface, it now appears that some, such as TLR3, may be localized intracellularly, perhaps in the lysosomal compartment.

ncbi gi num :

38454316

ncbi acc num :

NP_942086.1

ncbi gb acc num :

NM_198791.1

uniprot acc num :

Q7TNI8

ncbi mol weight :

103,175 Da

ncbi pathways :

Hepatitis C Pathway (173970); Hepatitis C Pathway (173907); Immune System Pathway (368381); Influenza A Pathway (217170); Influenza A Pathway (217150); Innate Immunity Signaling Pathway (368398); TRAF6 Mediated Induction Of Proinflammatory Cytokines Pathway (368414); Toll Like Receptor 3 (TLR3) Cascade Pathway (368411); Toll Receptor Cascades Pathway (368399); Toll-like Receptor Signaling Pathway (83468)

ncbi summary :

human homolog induces activation of NF-kappaB; mouse homolog plays a role in the production of inflammatory cytokines [RGD]

uniprot summary :

TLR3: a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. Most abundantly expressed in placenta and pancreas. Restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection. Acts via MyD88 and TRAF6, leading to the activation of NF-kappaB and the production of type I interferon. Protein type: Membrane protein, integral; Receptor, cytokine. Cellular Component: cell surface; lysosomal membrane; cytoplasm; integral to membrane; intracellular. Molecular Function: identical protein binding; transmembrane receptor activity; double-stranded RNA binding; receptor activity. Biological Process: positive regulation of interleukin-12 production; positive regulation of apoptosis; microglial cell activation; positive regulation of JNK cascade; defense response; positive regulation of interferon-alpha biosynthetic process; positive regulation of NF-kappaB import into nucleus; toll-like receptor 3 signaling pathway; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; response to exogenous dsRNA; positive regulation of interferon-beta production; positive regulation of interferon type I production; defense response to virus; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; response to virus; male gonad development; response to dsRNA; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of toll-like receptor signaling pathway; positive regulation of chemokine production; positive regulation of chemokine biosynthetic process; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; I-kappaB phosphorylation; positive regulation of inflammatory response; positive regulation of interferon-gamma biosynthetic process; microglial cell activation during immune response

size1 :

0.05 mg

price1 :

505 USD

more info or order :

MyBioSource product webpage