catalog number :
MBS194393
products full name :
Anti-DC-UbP Antibody
products short name :
DC-UbP
products name syn :
DC-UbP
other names :
ubiquitin domain-containing protein 2; Ubiquitin domain-containing protein 2; ubiquitin domain-containing protein 2; OTTHUMP00000161074; ubiquitin-like protein SB72; ubiquitin domain containing 2; Dendritic cell-derived ubiquitin-like protein; DC-UbP; Ubiquitin-like protein SB72
other gene names :
UBTD2; UBTD2; DCUBP; MGC30022; DCUBP
uniprot entry name :
UBTD2_HUMAN
specificity :
DC-UbP [Rabbit antibody to peptide corresponding to aa 197-212 of human DC-UbP.]. This antibody recognizes human, mouse, and rat DC-UbP.
form :
100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
storage stability :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
tested application :
ELISA
app notes :
ELISA: 1:1,000-1:10,000 with Dc-UbP on the solid phase. The investigator should determine the optimal dilution for their application.
other info1 :
Immunogen: Synthetic peptide corresponding to amino acids197-212 (SGRPLTDKMKFEELKI) of human DC-UbP precursor conjugated to KLH at the N-terminus. This sequence is 93% identical with those of mouse and rat DC-UbP.
other info2 :
Stabilizer: None. Preservatives: None. Available on request. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products categories :
Apoptosis Antibodies
products description :
DC-UbP is a 26 kDa ubiquitin-like protein from dendritic cells comprised of 106 amino acids. The ubiquitin domain in DC-UbP shares 28.6% identity with ubiquitin, but it does not have the conserved C-terminus Gly-Gly of ubiquitin required for ubiquitinization. DC-UbP is found in cytoplasm (particularly in mitochondria), and DC-UbP mRNA is expressed in various tumor cell types, but not in normal adult human tissues, which suggests a role for DC-UbP in tumorigenesis. In addition, DC-UbP appears to be downregulated during cellular differentiation and apoptosis.
products references :
Liu S, et al. 2003 Biochem Biophys Res Commun 300: 800-805.
ncbi acc num :
NP_689490.2
ncbi gb acc num :
NM_152277.2
ncbi mol weight :
26,190 Da
uniprot summary :
UBTD2: . Chromosomal Location of Human Ortholog: 5q35.1. Cellular Component: cytoplasm