catalog number :
MBS194390
products full name :
XAB2 Polyclonal Antibody
products short name :
XAB2
other names :
XAB2; Pre-mRNA-splicing factor SYF1; pre-mRNA-splicing factor SYF1; XPA-binding protein 2; crn-related protein kim1; SYF1 homolog, RNA splicing factor; XPA binding protein 2; Protein HCNP; XPA-binding protein 2
other gene names :
XAB2; XAB2; HCNP; HCRN; SYF1; NTC90; DKFZp762C1015; HCNP; KIAA1177; SYF1
uniprot entry name :
SYF1_HUMAN
specificity :
XAB2 [This rabbit antibody recognizes aa 840-855 of human XAB2 protein (XPA-binding protein 2).]. This antibody recognizes human XAB2 protein (XPA-binding protein 2) which appears to be involved in transcriptioncoupled DNA repair and transcription. XAB2 binds to XPA, a key factor in nucleotide excision repair pathways.
form :
100 ug affinity-purified antibody n PBS, pH 7.4.
storage stability :
This antibody is stable for at least one (1) year at -70 degree C. Avoid multiple freeze thaw cycles.
tested application :
Immunoblot
app notes :
Immunoblotting: use at 1:500-1:1,000 dilution. A band of approximately 100 kD (the monomeric form) is detected.
other info1 :
Antigen: Peptide corresponding to aa 840-855 of human XAB2 protein.
other info2 :
Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products categories :
Cancer Research Products
ncbi mol weight :
100,010 Da
ncbi pathways :
DNA Repair Pathway 105837!!Dual Incision Reaction In TC-NER Pathway 105892!!Formation Of Transcription-coupled NER (TC-NER) Repair Complex Pathway 105891!!Nucleotide Excision Repair Pathway 105883!!Spliceosome Pathway 125136!!Spliceosome Pathway 124832!!Transcription-coupled NER (TC-NER) Pathway 105890
uniprot summary :
Function: Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing. Ref.1. Subunit structure: Associates with RNA polymerase II, the TCR-specific proteins CKN1/CSA and ERCC6/CSB, and XPA. Identified in the spliceosome C complex. Ref.1. Subcellular location: Nucleus. By similarity. Note: Detected in the splicing complex carrying pre-mRNA. Sequence similarities: Belongs to the crooked-neck family.Contains 14 HAT repeats. Sequence caution: The sequence AAF86951.1 differs from that shown. Reason: Frameshift at positions 314, 411, 426, 429 and 468. The sequence AAH08778.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence BAB84861.1 differs from that shown. Reason: Alternative splicing. Incomplete sequence.