product summary
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company name :
MyBioSource
product type :
antibody
product name :
PUMA (CT) Polyclonal Antibody
catalog :
MBS194335
quantity :
0.1 mg
price :
370 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
rat
application :
western blot
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS194335
products type :
Antibody
products full name :
PUMA (CT) Polyclonal Antibody
products short name :
PUMA (CT)
products name syn :
PUMA (CT)
other names :
PUMA; Bcl-2-binding component 3; bcl-2-binding component 3; p53 up-regulated modulator of apoptosis; Bcl-2 binding component 3; p53 up-regulated modulator of apoptosis
other gene names :
Bbc3; Bbc3; Puma; Puma
uniprot entry name :
BBC3_RAT
clonality :
Polyclonal
host :
Rabbit
specificity :
PUMA (CT) [This rabbit antibody recognizes an epitope of aa 180-193 at the C-terminus of human and mouse PUMA (p53 Upregulated Modulator of Apoptosis).]. This antibody recognizes an epitope at the C-terminus of human and mouse PUMA (p53 Upregulated Modulator of Apoptosis). PUMA is a pro-apoptotic Bcl-2 family member that encodes two BH3 domain-containing proteins, PUMA- alpha and PUMA- beta . PUMA proteins bind Bcl-2, localize to mitochondria, and induce cytochrome c release and apoptosis in response to p53.
form :
100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
storage stability :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
tested application :
Immunoblot
app notes :
Immunoblotting: use at 1-2 ug/ml. In immunoblots, a band of 23 kD is detected. A lower molecular weight band at 16 kD is detected in MOLT4 and U937 cell lysates and probably represents the PUMA- beta protein. Positive control: Raji cell lysate.
other info1 :
Antigen: Peptide corresponding to aa 180-193 of human PUMA- alpha . This sequence is identical in human PUMA- alpha and PUMA- beta .
other info2 :
Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products categories :
Apoptosis Antibodies
ncbi gi num :
27542559
uniprot acc num :
Q80ZG6
ncbi mol weight :
20,718 Da
ncbi pathways :
Apoptosis Pathway (219785); Huntington's Disease Pathway (83492); Huntington's Disease Pathway (512); Measles Pathway (213300); Measles Pathway (213277); P53 Signaling Pathway (83447); P53 Signaling Pathway (465)
uniprot summary :
PUMA: Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Interacts with MCL1 and BCL2A1. Interacts with BCL2 and BCL2L1/BCL-XL. By DNA damage, glucocorticoid treatment, growth factor deprivation and p53/TP53. Ubiquitously expressed. Belongs to the Bcl-2 family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Mitochondrial. Cellular Component: mitochondrion; intracellular. Molecular Function: protein binding. Biological Process: caspase activation; release of cytochrome c from mitochondria; glial cell differentiation; positive regulation of protein homooligomerization; positive regulation of apoptosis; release of sequestered calcium ion into cytosol; positive regulation of neuron apoptosis; reduction of endoplasmic reticulum calcium ion concentration; determination of adult life span; brain development; response to DNA damage stimulus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of growth
size1 :
0.1 mg
price1 :
370 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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