catalog number :
MBS194326
products full name :
PHAP (NT) Polyclonal Antibody
products short name :
PHAP (NT)
products name syn :
PHAP (NT)
uniprot entry name :
Q52JJ7_BACTU
specificity :
PHAP (NT) [Rabbit polyclonal antibody to PHAP (NT)]. This antibody recognizes all three identified isoforms of human, mouse and rat PHAP, including PHAP I, PHAP I2a, and PHAP III. The PHAP proteins (tumor suppressor putative HLA-DR associated proteins) are important regulators of mitochondrial apoptosis. PHAP facilitates apoptosome-mediated caspase-9 activation to stimulate the mitochondrial apoptosis pathway. In addition, PHAP opposes both Ras- and myc- mediated cell transformation.
form :
100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
storage stability :
Store at 4 degree C; stable for one year
tested application :
Western Blot
app notes :
Western Blot: Use at 0.5-2 ug/ml. Using Raji cell lysate as a positive control, a band of approximately 35 kD is detected corresponding to PHAP III, with a doublet below PHAP III corresponding to PHAP I (upper) and PHAP I2a (lower).
other info1 :
Antigen: A synthetic peptide close to the amino terminus of human PHAP.
other info2 :
Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products categories :
Apoptosis Antibodies
ncbi acc num :
AAY16100.1
ncbi mol weight :
20,405 Da
ncbi pathways :
Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Salmonella Infection Pathway (375172); Salmonella Infection Pathway (375149)