catalog number :
MBS194249
products full name :
GRIM-19 Polyclonal Antibody
products short name :
GRIM-19
products name syn :
GRIM-19
other names :
GRIM-19 protein; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13-A; GRIM-19 protein; Protein MATERNAL EFFECT EMBRYO ARREST 4
other gene names :
MEE4; MEE4; maternal effect embryo arrest 4; MEE4; T1G11.12; T1G11_12
uniprot entry name :
NDADA_ARATH
specificity :
GRIM-19 [This rabbit antibody recognizes human GRIM-19 (Genes associated with Retinoid-IFN-induced Mortality), a nuclear protein that functions as a cell death regulatory molecule]. This antibody recognizes human GRIM- 19 (Genes associated with Retinoid- IFN-induced Mortality), a nuclear protein that functions as a cell death regulatory molecule. Antisense expression of GRIM-19 confers a strong resistance to IFN/RA-induced death by reducing the intracellular levels of GRIM-19 protein. Overexpression of GRIM-19 enhances cell death in response to IFN/RA.
form :
100 ug IgG in 100 ul PBS, pH7.4, purified by immunoaffinity chromatography.
storage stability :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
tested application :
Immunoblot
app notes :
Immunoblotting: use at 1:500-1:1,000 dilution. A band of approx. 16 kD is detected.
other info1 :
Antigen: Recombinant human GRIM-19 protein
other info2 :
Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products categories :
Apoptosis Antibodies
ncbi acc num :
NP_171957.2
ncbi gb acc num :
NM_100342.4
ncbi mol weight :
16,126 Da
ncbi pathways :
Oxidative Phosphorylation Pathway (4000); Oxidative Phosphorylation Pathway (303)
uniprot summary :
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Subunit structure: Complex I is composed of at least 49 different subunits. Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Sequence similarities: Belongs to the complex I NDUFA13 subunit family. Sequence caution: The sequence AAB80637.1 differs from that shown. Reason: Erroneous gene model prediction.