Glucocorticoid Receptor Polyclonal Antibody | MyBioSource MBS194233 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Glucocorticoid Receptor Polyclonal Antibody

catalog :

MBS194233

quantity :

0.2 mL

price :

410 USD

clonality :

polyclonal

host :

sheep

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS194233

products type :

Antibody

products full name :

Glucocorticoid Receptor Polyclonal Antibody

products short name :

Glucocorticoid Receptor

products name syn :

Anti-Glucocorticoid Receptor; Glucocorticoid Receptor

other names :

glucocorticoid receptor; Glucocorticoid receptor; glucocorticoid receptor; OTTHUMP00000160084; OTTHUMP00000160085; OTTHUMP00000222851; OTTHUMP00000222854; OTTHUMP00000222855; OTTHUMP00000222858; glucocorticoid nuclear receptor variant 1; nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); Nuclear receptor subfamily 3 group C member 1

other gene names :

NR3C1; NR3C1; GR; GCR; GRL; GCCR; GRL

uniprot entry name :

GCR_HUMAN

clonality :

Polyclonal

host :

Sheep

sequence length :

777

specificity :

Anti-Glucocorticoid Receptor [Polyclonal (sheep) antibody recognizes human and monkey glucocorticoid receptor.]. This antibody reacts specifically with monkey and human glucocorticoid receptor.

storage stability :

This antibody is stable for at least one (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

tested application :

Western Blot

app notes :

This antibody has been used successfully in Western Blot assays (1:500-1:1000 dilution) to identify human glucocorticoid receptor. Other applications are under investigation.

other info1 :

Antigen: Peptide consisting of amino acids 150-175 of squirrel monkey glucocorticoid receptor coupled to diptheria toxoid. This sequence is identical in human glucocorticoid receptor except for 2 amino acids (underlined):. N terminus - APKEKEFPKTHSDVSSEQQNLKGQTG- NH2 - C terminus.

other info2 :

Preservatives: None. Available on request. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

products categories :

Hormone and Serum Protein Antibodies

ncbi gi num :

239758

ncbi acc num :

AAB20466.1

uniprot acc num :

P04150

ncbi mol weight :

85,659 Da

ncbi pathways :

Adipogenesis Pathway (198832); Androgen Receptor Signaling Pathway (198806); Circadian Clock Pathway (187173); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Glucocorticoid Receptor Regulatory Network Pathway (138014); IL-2 Signaling Pathway (198885); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462)

ncbi summary :

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq]

uniprot summary :

GR: transcription factor of the nuclear receptor family. Receptor for glucocorticoids (GC). Binds to glucocorticoid response elements (GRE) and modulates other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Three alternatively spliced isoforms have been described. Protein type: Nuclear receptor; Transcription factor; Mitochondrial; DNA-binding. Chromosomal Location of Human Ortholog: 5q31.3. Cellular Component: nucleoplasm; membrane; mitochondrial matrix; cytoplasm; cytosol; nucleus. Molecular Function: protein dimerization activity; glucocorticoid receptor activity; protein binding; zinc ion binding; transcription factor activity; steroid binding. Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; adrenal gland development; maternal behavior; regulation of glucocorticoid biosynthetic process; chromatin modification; signal transduction; glucocorticoid metabolic process; glucocorticoid mediated signaling; regulation of transcription, DNA-dependent; glucocorticoid receptor signaling pathway; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; gene expression; regulation of gluconeogenesis. Disease: Glucocorticoid Resistance, Generalized

size1 :

0.2 mL

price1 :

410 USD

more info or order :

MyBioSource product webpage