product summary
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company name :
MyBioSource
product type :
antibody
product name :
EndoG Polyclonal Antibody
catalog :
MBS194228
quantity :
0.1 mg
price :
370 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot
more info or order :
product information
catalog number :
MBS194228
products type :
Antibody
products full name :
EndoG Polyclonal Antibody
products short name :
EndoG
products name syn :
EndoG
other names :
endonuclease G, mitochondrial; Endonuclease G, mitochondrial; endonuclease G, mitochondrial; endo G; OTTHUMP00000022301; mitochondrial endonuclease G; endonuclease G
other gene names :
ENDOG; ENDOG; FLJ27463
uniprot entry name :
NUCG_HUMAN
clonality :
Polyclonal
host :
Rabbit
sequence length :
297
specificity :
EndoG [This rabbit antibody recognizes aa 55-70 of human, mouse, and rat EndoG (Endonuclease G).]. This antibody recognizes human, mouse, and rat EndoG (Endonuclease G) an enzyme that is activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD. EndoG is a mitochondriaspecific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis.
form :
100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
storage stability :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
tested application :
Immunoblot
app notes :
Immunoblotting: use at 1-2 ug/ml. In immunoblots, a band of 35 kD is detected. Positive control: HepG2 cell lysate.
other info1 :
Antigen: Peptide corresponding to aa 55-70 of human EndoG.
other info2 :
Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
products categories :
Apoptosis Antibodies
ncbi gi num :
53759134
ncbi acc num :
NP_004426.2
ncbi gb acc num :
NM_004435.2
uniprot acc num :
Q14249
ncbi mol weight :
32,620 Da
ncbi pathways :
Apoptosis Pathway (83060); Apoptosis Pathway (470)
ncbi summary :
The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq]
uniprot summary :
ENDOG: Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. Homodimer. Belongs to the DNA/RNA non-specific endonuclease family. Protein type: Ribonuclease; EC 3.1.30.-; Apoptosis; Mitochondrial; Deoxyribonuclease. Chromosomal Location of Human Ortholog: 9q34.1. Cellular Component: mitochondrion. Molecular Function: protein binding; nuclease activity; nucleic acid binding; endonuclease activity; metal ion binding. Biological Process: response to antibiotic; in utero embryonic development; positive regulation of apoptosis; DNA fragmentation during apoptosis; DNA recombination
size1 :
0.1 mg
price1 :
370 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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