Cyclin E1 Polyclonal Antibody | MyBioSource MBS194213 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Cyclin E1 Polyclonal Antibody

catalog :

MBS194213

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS194213

products type :

Antibody

products full name :

Cyclin E1 Polyclonal Antibody

products short name :

Cyclin E1

products name syn :

Anti-Cyclin E1; Cyclin E1

other names :

Cyclin E1; G1/S-specific cyclin-E1; G1/S-specific cyclin-E1; cyclin Es; cyclin Et; cyclin E1

other gene names :

CCNE1; CCNE1; CCNE; CCNE

uniprot entry name :

CCNE1_HUMAN

clonality :

Polyclonal

host :

Rabbit

sequence length :

410

specificity :

Anti-Cyclin E1 [Rabbit antibody to peptide corresponding to aa 43-52 of human cyclin E1]. This antibody recognizes human cyclin E1, a protein (approx. 50 kD) expressed in elevated levels in human tumor cells. Cyclin E1 controls the initiation of DNA synthesis by activating cdk2, and i expression of cyclin E1 is upregulated by the E7 oncoprotein.

form :

100 ug affinity-purified antibodyin PBS, pH 7.4

storage stability :

This antibody is stable for at least one (1) year at -70 degree C. Avoid multiple freeze thaw cycles.

tested application :

Immunoblot

app notes :

Immunoblotting: use at 1:500-1:1,000.

other info1 :

Antigen: Peptide corresponding toamino acids 43-52 of cyclin E1.

other info2 :

Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

products categories :

Cancer Research Products

ncbi gi num :

23273784

ncbi acc num :

AAH35498.1

uniprot acc num :

P24864

ncbi mol weight :

47,077 Da

ncbi pathways :

Androgen Receptor Signaling Pathway (198806); B Cell Receptor Signaling Pathway (198909); BARD1 Signaling Events Pathway (137959); Cell Cycle Checkpoints Pathway (105739); Cell Cycle, Mitotic Pathway (105765); Cell Cycle Pathway (198811); Cell Cycle Pathway (83054); Cell Cycle Pathway (463); Cyclin A:Cdk2-associated Events At S Phase Entry Pathway (105783); Cyclin E Associated Events During G1/S Transition Pathway (105770)

ncbi summary :

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq]

uniprot summary :

CCNE1: a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Two alternatively spliced isoforms have been described. Protein type: Activator; Nuclear receptor co-regulator; Cell cycle regulation. Chromosomal Location of Human Ortholog: 19q12. Cellular Component: nucleoplasm; cyclin-dependent protein kinase holoenzyme complex; cytosol; nucleus. Molecular Function: protein binding; androgen receptor binding; transcription coactivator activity; kinase activity; cyclin-dependent protein kinase regulator activity; protein kinase binding. Biological Process: G1/S-specific transcription in mitotic cell cycle; Wnt receptor signaling pathway; DNA replication initiation; cell division; regulation of cell cycle; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; mitotic cell cycle; regulation of protein kinase activity; protein amino acid phosphorylation; G1/S transition of mitotic cell cycle

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage